Journal article
Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureus
Bioorganic & medicinal chemistry letters, Vol.13(10), pp.1745-1749
2003
DOI: 10.1016/S0960-894X(03)00208-7
PMID: 12729656
Abstract
The synthesis of symmetric and asymmetric piperazinyl-linked dimers of the fluoroquinolone class of antibiotics is described. Specific dimers are shown to possess potent antibacterial activity against drug-resistant strains of
Staphylococcus aureus, including strains possessing resistance due to the NorA multidrug efflux pump and a mutation in the quinolone resistance-determining region of topoisomerase IV.
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Details
- Title: Subtitle
- Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureus
- Creators
- Robert J. Kerns - Division of Medicinal and Natural Products Chemistry, The University of Iowa, Iowa City, IA 52242, USAMichael J. Rybak - Wayne State UniversityGlenn W. Kaatz - Wayne State UniversityFlamur Vaka - Wayne State UniversityRaymond Cha - Wayne State UniversityRichard G. Grucz - Wayne State UniversityVeena U. Diwadkar - Wayne State UniversityTracey D. Ward - Wayne State University
- Resource Type
- Journal article
- Publication Details
- Bioorganic & medicinal chemistry letters, Vol.13(10), pp.1745-1749
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0960-894X(03)00208-7
- PMID
- 12729656
- ISSN
- 0960-894X
- eISSN
- 1464-3405
- Language
- English
- Date published
- 2003
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984366016702771
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