Pituitary Glycoprotein Hormones in Human Milk before and after Pasteurization or Refrigeration

Reka A. Vass; Robert D. Roghair; Edward F. Bell; Tarah T. Colaizy; Karen J. Johnson; Mendi L. Schmelzel; Jacky R. Walker; Tibor Ertl

doi:10.3390/nu12030687

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Pituitary Glycoprotein Hormones in Human Milk before and after Pasteurization or Refrigeration

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Pituitary Glycoprotein Hormones in Human Milk before and after Pasteurization or Refrigeration

Reka A. Vass, Robert D. Roghair, Edward F. Bell, Tarah T. Colaizy, Karen J. Johnson, Mendi L. Schmelzel, Jacky R. Walker and Tibor Ertl

Nutrients, Vol.12(3), p.687

03/01/2020

DOI: 10.3390/nu12030687

PMCID: PMC7146501

PMID: 32143273

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Abstract

Our aims were to investigate the presence of pituitary glycoprotein hormones in preterm and donor milk, and to examine the effects of Holder pasteurization and refrigeration on the levels of these hormones. We measured follicle-stimulating hormone (FSH), luteinizing hormone (LH), and thyroid-stimulating hormone (TSH) in milk samples from mothers who delivered prematurely (n = 27) and in samples of mothers who delivered at term and donated milk to the Mother's Milk Bank of Iowa (n = 30). The gonadotropins and TSH were present in similar amounts within human milk produced for preterm and term infants. FSH increased 21% after refrigeration (p < 0.05), while LH declined by 39% (p < 0.05). Holder pasteurization decreased LH by 24% (p < 0.05) and increased TSH by 17% (p < 0.05). Holder pasteurization followed by refrigeration resulted in a 21% increase in FSH and a 41% decrease in LH (both p < 0.05), resulting in more than a 3-fold increase in donor milk FSH:LH ratios (p < 0.05 versus fresh donor milk). Despite structural similarities, the gonadotropins are differentially impacted by Holder pasteurization and refrigeration, and this results in marked alterations in the relative amount of FSH and LH that may be administered to preterm infants, potentially swinging hormonal balance towards ovarian hyperstimulation in females and hypogonadism in males.

Life Sciences & Biomedicine

Nutrition & Dietetics

Science & Technology

Details

Title: Subtitle: Pituitary Glycoprotein Hormones in Human Milk before and after Pasteurization or Refrigeration
Creators: Reka A. Vass - University of Pecs
Robert D. Roghair - University of Iowa
Edward F. Bell - University of Iowa
Tarah T. Colaizy - University of Iowa
Karen J. Johnson - University of Iowa
Mendi L. Schmelzel - University of Iowa
Jacky R. Walker - University of Iowa
Tibor Ertl - University of Pecs
Resource Type: Journal article
Publication Details: Nutrients, Vol.12(3), p.687
DOI: 10.3390/nu12030687
PMID: 32143273
PMCID: PMC7146501
NLM abbreviation: Nutrients
ISSN: 2072-6643
eISSN: 2072-6643
Publisher: Mdpi
Number of pages: 10
Grant note: Iowa-Pecs Neonatology Collaborative Research Fund, Department of Pediatrics, University of Iowa UNKP-19-3-I / New National Excellence Program of the Hungarian Ministry for Innovation and Technology GINOP-2.3.2-15-2016-00021 / Economic Development and Innovation Operational Program of the Government of Hungary
Language: English
Date published: 03/01/2020
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984353846702771

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