Journal article
Pitx2, a Bicoid-Type Homeobox Gene, Is Involved in a Lefty-Signaling Pathway in Determination of Left-Right Asymmetry
Cell (Cambridge), Vol.94(3), pp.299-305
1998
DOI: 10.1016/S0092-8674(00)81473-7
PMID: 9708732
Abstract
Signaling molecules such as Activin, Sonic hedgehog, Nodal, Lefty, and Vg1 have been found to be involved in determination of left-right (L-R) asymmetry in the chick, mouse, or frog. However, a common signaling pathway has not yet been identified in vertebrates. We report that
Pitx2, a bicoid-type homeobox gene expressed asymmetrically in the left lateral plate mesoderm, may be involved in determination of L-R asymmetry in both mouse and chick. Since
Pitx2 appears to be downstream of
lefty-1 in the mouse pathway, we examined whether mouse Lefty proteins could affect the expression of
Pitx2 in the chick. Our results indicate that a common pathway from
lefty-1 to
Pitx2 likely exists for determination of L-R asymmetry in vertebrates.
Details
- Title: Subtitle
- Pitx2, a Bicoid-Type Homeobox Gene, Is Involved in a Lefty-Signaling Pathway in Determination of Left-Right Asymmetry
- Creators
- Hidefumi Yoshioka - Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, 2-1 Minami-Jyosanjima-cho, Tokushima 770-8506, JapanChikara Meno - Institute for Molecular and Cellular Biology, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, JapanKazuko Koshiba - Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, 2-1 Minami-Jyosanjima-cho, Tokushima 770-8506, JapanMinoru Sugihara - Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, 2-1 Minami-Jyosanjima-cho, Tokushima 770-8506, JapanHiroyuki Itoh - Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, 2-1 Minami-Jyosanjima-cho, Tokushima 770-8506, JapanYoshiyasu Ishimaru - Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, 2-1 Minami-Jyosanjima-cho, Tokushima 770-8506, JapanTakashi Inoue - Tokushima UniversityHideyo Ohuchi - Department of Genetic Biochemistry, Faculty of Pharmaceutical Sciences, Kyoto University Graduate School, of Pharmaceutical Sciences, Kyoto 606-8501, JapanElena V Semina - Departments of Pediatrics and Biological Sciences, The University of Iowa, Iowa City Iowa 52242, USAJeffrey C Murray - Departments of Pediatrics and Biological Sciences, The University of Iowa, Iowa City Iowa 52242, USAHiroshi Hamada - Institute for Molecular and Cellular Biology, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, JapanSumihare Noji - Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, 2-1 Minami-Jyosanjima-cho, Tokushima 770-8506, Japan
- Resource Type
- Journal article
- Publication Details
- Cell (Cambridge), Vol.94(3), pp.299-305
- DOI
- 10.1016/S0092-8674(00)81473-7
- PMID
- 9708732
- NLM abbreviation
- Cell
- ISSN
- 0092-8674
- eISSN
- 1097-4172
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/501100002241, name: Japan Science and Technology Agency; DOI: 10.13039/501100003382, name: Core Research for Evolutional Science and Technology; DOI: 10.13039/501100001695, name: Japan Science and Technology Corporation; DOI: 10.13039/501100001700, name: Ministry of Education, Culture, Sports, Science and Technology
- Language
- English
- Date published
- 1998
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025676202771
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