Placenta-Specific Protein 1: A Potential Key to Many Oncofetal-Placental OB/GYN Research Questions

Eric Devor; Henry Reyes; Donna Santillan; Mark Santillan; Chinenye Onukwugha; Michael Goodheart; Kimberly Leslie

doi:10.1155/2014/678984

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Placenta-Specific Protein 1: A Potential Key to Many Oncofetal-Placental OB/GYN Research Questions

Journal article

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Peer reviewed

Placenta-Specific Protein 1: A Potential Key to Many Oncofetal-Placental OB/GYN Research Questions

Eric Devor, Henry Reyes, Donna Santillan, Mark Santillan, Chinenye Onukwugha, Michael Goodheart and Kimberly Leslie

Obstetrics and Gynecology International, Vol.2014, pp.1-5

2014

DOI: 10.1155/2014/678984

PMCID: PMC3976915

PMID: 24757447

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Abstract

Placenta-specific protein 1 (PLAC1) is a secreted protein found in trophoblasts. Several reports implicate a central role for PLAC1 in establishment and maintenance of the placenta. In addition to placentae PLAC1 is expressed in a variety of solids including breast, endometrial, and ovarian cancers. In order to show that PLAC1 is potentially relevant to a number of research questions in OB/GYN, we report on PLAC1 expression in a selected panel that includes two choriocarcinoma cell lines, normal placental tissues, and endometrial and ovarian tumors. We report for the first time that PLAC1 is also expressed in human fetal tissues. PLAC1 is transcriptionally heterogeneous with one promoter (P1) generating two transcripts with alternately spliced 5' UTRs and the other promoter (P2) generating a third transcript. Placental tissues favor P2 transcripts, while P1 is favored in most of the other cells. Mechanisms determining multiple PLAC1 transcripts and promoter preferences are as yet unknown, but it is clear that this protein is likely to be important in a variety of phenomena relevant to both gynecologic oncology and maternal-fetal medicine.

Details

Title: Subtitle: Placenta-Specific Protein 1: A Potential Key to Many Oncofetal-Placental OB/GYN Research Questions
Creators: Eric Devor
Henry Reyes
Donna Santillan
Mark Santillan
Chinenye Onukwugha
Michael Goodheart
Kimberly Leslie
Resource Type: Journal article
Publication Details: Obstetrics and Gynecology International, Vol.2014, pp.1-5
DOI: 10.1155/2014/678984
PMID: 24757447
PMCID: PMC3976915
NLM abbreviation: Obstet Gynecol Int
ISSN: 1687-9597
eISSN: 1687-9589
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: RO1CA99908, K12HD000849, 5K12HD063117-04, W81XWH-12-1-0117, W81XWH-13-1-0178
Language: English
Date published: 2014
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9983931810502771

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