Placental Injury and Antibody Transfer after Coronavirus Disease 2019 in Pregnancy

Patience Timi; Sarah E. Kellerhals; Naima T. Joseph; Carolynn M. Dude; Hans P. Verkerke; Les'Shon S. Irby; Alicia K. Smith; Sean R. Stowell; Denise J. Jamieson; Martina L. Badell

doi:10.1093/infdis/jiac270

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Placental Injury and Antibody Transfer after Coronavirus Disease 2019 in Pregnancy

Journal article

Open access

Peer reviewed

Placental Injury and Antibody Transfer after Coronavirus Disease 2019 in Pregnancy

Patience Timi, Sarah E. Kellerhals, Naima T. Joseph, Carolynn M. Dude, Hans P. Verkerke, Les'Shon S. Irby, Alicia K. Smith, Sean R. Stowell, Denise J. Jamieson and Martina L. Badell

The Journal of infectious diseases, Vol.227(7), pp.850-854

04/12/2023

DOI: 10.1093/infdis/jiac270

PMCID: PMC9384443

PMID: 35767286

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Abstract

Background We examined the relationship between placental histopathology and transplacental antibody transfer in pregnant patients after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods Differences in plasma concentrations of anti-receptor biding domain (RBD) immunoglobulin (Ig)G antibodies in maternal and cord blood were analyzed according to presence of placental injury. Results Median anti-RBD IgG concentrations in cord blood with placental injury (n = 7) did not differ significantly from those without injury (n = 16) (median 2.7 [interquartile range {IQR}, 1.8-3.6] vs 2.7 [IQR, 2.4-2.9], P = 0.59). However, they were associated with lower transfer ratios (median 0.77 [IQR, 0.61-0.97] vs 0.97 [IQR, 0.80-1.01], P = 0.05). Conclusions SARS-CoV-2 placental injury may mediate reduced maternal-fetal antibody transfer.

Immunology

Infectious Diseases

Life Sciences & Biomedicine

Microbiology

Science & Technology

Details

Title: Subtitle: Placental Injury and Antibody Transfer after Coronavirus Disease 2019 in Pregnancy
Creators: Patience Timi - Emory University
Sarah E. Kellerhals - University of Arizona
Naima T. Joseph - Emory University
Carolynn M. Dude - Emory University
Hans P. Verkerke - Emory University
Les'Shon S. Irby - Emory University
Alicia K. Smith - Emory University
Sean R. Stowell - Brigham and Women's Hospital
Denise J. Jamieson - Emory University
Martina L. Badell - Emory University
Resource Type: Journal article
Publication Details: The Journal of infectious diseases, Vol.227(7), pp.850-854
Publisher: Oxford Univ Press
DOI: 10.1093/infdis/jiac270
PMID: 35767286
PMCID: PMC9384443
ISSN: 0022-1899
eISSN: 1537-6613
Number of pages: 5
Grant note: Emory University School of Medicine Woodruff Health Sciences Synergy Award Emory Medical Care Foundation
Language: English
Date published: 04/12/2023
Academic Unit: Obstetrics and Gynecology; VPMA - Administration
Record Identifier: 9984446067902771

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