Journal article
Plaque development, vessel curvature, and wall shear stress in coronary arteries assessed by X-ray angiography and intravascular ultrasound
Medical image analysis, Vol.10(4), pp.615-631
2006
DOI: 10.1016/j.media.2006.03.002
PMCID: PMC2590653
PMID: 16644262
Abstract
The relationships among vascular geometry, hemodynamics, and plaque development in the coronary arteries are complex and not yet well understood. This paper reports a methodology for the quantitative analysis of in vivo coronary morphology and hemodynamics, with particular emphasis placed on the critical issues of image segmentation and the automated classification of disease severity. We were motivated by the observation that plaque more often developed at the inner curvature of a vessel, presumably due to the relatively lower wall shear stress at these locations. The presented studies are based on our validated methodology for the three-dimensional fusion of intravascular ultrasound (IVUS) and X-ray angiography, introducing a novel approach for IVUS segmentation that incorporates a robust, knowledge-based cost function and a fully optimal, three-dimensional segmentation algorithm. Our first study shows that circumferential plaque distribution depends on local vessel curvature in the majority of vessels. The second study analyzes the correlation between plaque distribution and wall shear stress in a set of 48 in vivo vessel segments. The results were conclusive for both studies, with a stronger correlation of circumferential plaque thickness with local curvature than with wall shear stress. The inverse relationship between local wall shear stress and plaque thickness was significantly more pronounced (
p
<
0.025) in vessel cross sections exhibiting compensatory enlargement (positive remodeling) without luminal narrowing than when the full spectrum of disease severity was considered. The inverse relationship was no longer observed in vessels where less than 35% of vessel cross sections remained without luminal narrowing. The findings of this study confirm, in vivo, the hypothesis that relatively lower wall shear stress is associated with early plaque development.
Details
- Title: Subtitle
- Plaque development, vessel curvature, and wall shear stress in coronary arteries assessed by X-ray angiography and intravascular ultrasound
- Creators
- Andreas Wahle - Department of Electrical and Computer Engineering, The University of Iowa, 4016 Seamans Center, Iowa City, IA 52242, USAJohn J Lopez - Department of Medicine, Division of Cardiology, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USAMark E Olszewski - Department of Electrical and Computer Engineering, The University of Iowa, 4016 Seamans Center, Iowa City, IA 52242, USASarah C Vigmostad - Department of Biomedical Engineering, The University of Iowa, 1402 Seamans Center, Iowa City, IA 52242, USAKrishnan B Chandran - Department of Biomedical Engineering, The University of Iowa, 1402 Seamans Center, Iowa City, IA 52242, USAJames D Rossen - Department of Internal Medicine, The University of Iowa, 4212 Roy Carver Pavilion, Iowa City, IA 52242, USAMilan Sonka - Department of Electrical and Computer Engineering, The University of Iowa, 4016 Seamans Center, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Medical image analysis, Vol.10(4), pp.615-631
- DOI
- 10.1016/j.media.2006.03.002
- PMID
- 16644262
- PMCID
- PMC2590653
- NLM abbreviation
- Med Image Anal
- ISSN
- 1361-8415
- eISSN
- 1361-8423
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 2006
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Electrical and Computer Engineering; Cardiovascular Medicine; Surgery; Radiation Oncology; Injury Prevention Research Center; Neurosurgery; Mechanical Engineering; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984020755602771
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