Journal article
Plasma Biomarkers of Alzheimer's Disease in African Americans
Journal of Alzheimer's disease, Vol.79(1), pp.323-334
01/01/2021
DOI: 10.3233/JAD-200828
PMID: 33252078
Abstract
Background/Objective: The aim of this study was to determine if plasma concentrations of 5 surrogate markers of Alzheimer's disease (AD) pathology and neuroinflammation are associated with disease status in African Americans.
Methods: We evaluated 321 African Americans (159 AD, 162 controls) from the Florida Consortium for African-American Alzheimer's Disease Studies (FCA(3)DS). Five plasma proteins reflecting AD neuropathology or inflammation (A beta(42), tau, IL6, IL10, TNF alpha) were tested for associations with AD, age, sex, APOE and MAPT genotypes, and for pairwise correlations.
Results: Plasma tau levels were higher in AD when adjusted for biological and technical covariates. APOE epsilon 4 was associated with lower plasma A beta(42) and tau levels. Older age was associated with higher plasma A beta(42), tau, and TNF alpha. Females had lower IL10 levels. Inflammatory proteins had strong pairwise correlations amongst themselves and with A beta(42).
Conclusion: We identified effects of demographic and genetic variants on five potential plasma biomarkers in African Americans. Plasma inflammatory biomarkers and A beta(42) may reflect correlated pathologies and elevated plasma tau may be a biomarker of AD in this population.
Details
- Title: Subtitle
- Plasma Biomarkers of Alzheimer's Disease in African Americans
- Creators
- Kaancan Deniz - Mayo Clinic in FloridaCharlotte C. G. Ho - Mayo Clinic in FloridaKimberly G. Malphrus - Mayo Clinic in FloridaJoseph S. Reddy - Mayo Clinic in FloridaThuy Nguyen - Mayo Clinic in FloridaTroy P. Carnwath - Mayo Clinic in FloridaJulia E. Crook - Mayo Clinic in FloridaJohn A. Lucas - Mayo Clinic in FloridaNeill R. Graff-Radford - Mayo Clinic in FloridaMinerva M. Carrasquillo - Mayo Clinic in FloridaNilufer Ertekin-Taner - Mayo Clinic in Florida
- Resource Type
- Journal article
- Publication Details
- Journal of Alzheimer's disease, Vol.79(1), pp.323-334
- DOI
- 10.3233/JAD-200828
- PMID
- 33252078
- NLM abbreviation
- J Alzheimers Dis
- ISSN
- 1387-2877
- eISSN
- 1875-8908
- Publisher
- Sage
- Number of pages
- 12
- Grant note
- 5AZ03; 7AZ17; 7AZ07 / Florida Health Ed and Ethel Moore Alzheimer's Disease Mayo Clinic Office of Health Disparities in Research U01AG046139; R01AG061796 / National Institute on Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) RF AG051504; U01 AG046139; R01 AG061796; P30 AG062677 / National Institute on Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Language
- English
- Date published
- 01/01/2021
- Academic Unit
- Neurology
- Record Identifier
- 9985180932002771
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