Journal article
Plasma Cathelicidin is Independently Associated with Reduced Lung Function in COPD: Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort
Chronic obstructive pulmonary diseases, Vol.7(4), pp.370-381
10/25/2020
DOI: 10.15326/jcopdf.7.4.2020.0142
PMCID: PMC7883905
PMID: 33108110
Abstract
Rationale:
The antimicrobial peptide cathelicidin, also known in humans as LL-37, is a defensin secreted by immune and airway epithelial cells. Deficiencies in this peptide may contribute to adverse pulmonary outcomes in chronic obstructive pulmonary disease (COPD).
Objectives:
Using clinical and biological samples from the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), we assessed the associations of plasma cathelicidin levels with cross-sectional and longitudinal COPD outcomes.
Methods:
A total of 1609 SPIROMICS participants with COPD and available plasma samples were analyzed. Cathelicidin was modeled dichotomously (lowest quartile [< 50 ng/ml] versus highest 75% [≥ 50 ng/ml]) and continuously per 10 ng/ml. Fixed-effect multilevel regression analyses were used to assess associations between cathelicidin and cross-sectional as well as longitudinal lung function. The associations between cathelicidin and participant-reported retrospective and prospective COPD exacerbations were assessed via logistic regression.
Measurements and Main Results:
Cathelicidin < 50 ng/ml (N=383) was associated with female sex, black race, and lower body mass index (BMI).At baseline,cathelicidin < 50 ng/ml was independently associated with 3.55% lower % predicted forced expiratory volume in 1 second (FEV
1
)(95% confidence interval [CI] -6.22% to -0.88% predicted;
p
=0.01), while every 10 ng/ml lower cathelicidin was independently associated with 0.65% lower % predicted FEV
1
(95% CI -1.01% to -0.28% predicted;
p
< 0.001). No independent associations with longitudinal lung function decline or participant-reported COPD exacerbations were observed.
Conclusions:
Reduced cathelicidin is associated with lower lung function at baseline. Plasma cathelicidin may potentially identify COPD patients at increased risk for more severe lung disease.
Details
- Title: Subtitle
- Plasma Cathelicidin is Independently Associated with Reduced Lung Function in COPD: Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort
- Creators
- Robert M. Burkes - University of North Carolina at Chapel HillAgathe S. Ceppe - University of North Carolina at Chapel HillDavid J. Couper - University of North Carolina at Chapel HillAlejandro P. Comellas - University of IowaJ. Michael Wells - University of Alabama at BirminghamStephen P. Peters - Wake Forest UniversityGerard J. Criner - Temple UniversityRichard E. Kanner - University of UtahRobert Paine III - Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake CityStephanie A. Christenson - University of California, San FranciscoChristopher B. Cooper - University of California, Los AngelesIgor Z. Barjaktarevic - University of California, Los AngelesJerry A. Krishnan - University of Illinois ChicagoWassim W. Labaki - University of MichiganMeiLan K. Han - University of MichiganJeffrey L. Curtis - University of Michigan–Ann ArborNadia N. Hansel - Johns Hopkins UniversityRobert A. Wise - Johns Hopkins UniversityM. Bradley Drummond - University of North Carolina at Chapel HillSubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) collaborators
- Contributors
- Eric A Hoffman (Contributor) - University of Iowa, Radiology
- Resource Type
- Journal article
- Publication Details
- Chronic obstructive pulmonary diseases, Vol.7(4), pp.370-381
- DOI
- 10.15326/jcopdf.7.4.2020.0142
- PMID
- 33108110
- PMCID
- PMC7883905
- NLM abbreviation
- Chronic Obstr Pulm Dis
- ISSN
- 2372-952X
- eISSN
- 2372-952X
- Publisher
- COPD Foundation Inc
- Alternative title
- Plasma Cathelicidin and COPD Outcomes
- Language
- English
- Date published
- 10/25/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Pulmonary, Critical Care, and Occupational Medicine; ICTS; Internal Medicine
- Record Identifier
- 9984318804402771
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