Journal article
Plasma Glutamate Concentrations in 1-Year-Old Infants and Adults Ingesting Monosodium L-Glutamate in Consommé
Pediatric research, Vol.20(1), pp.53-58
01/1986
DOI: 10.1203/00006450-198601000-00014
PMID: 3945516
Abstract
This study tested the hypothesis that infants metabolize glutamate more slowly than adults. Eight 1-yr-old infants ingested 160 ml of a beef consomme providing monosodium L-glutamate at 0, 25, and 50 mg/kg body weight. Plasma glutamate and aspartate concentrations were measured sequentially for the next 2 h. The results were compared to values noted in nine adult subjects ingesting equivalent doses of monosodium L-glutamate in consomme. In adults, mean (± SD) peak plasma glutamate concentrations were 5.59 ± 1.56, 10.2 ± 2.08, and 17.0 ± 8.06 /imol/dl, respectively; the area under the plasma glutamate concentration time curves were 96 ± 42, 257 ± 80, and 442 ± 303 µmol/dl x min, respectively. In infants, the mean (±SD) peak plasma glutamate concentrations were 6.94 ± 1.43,10.6 ± 2.36, and 12.0 ± 1.16 jimol/dl, respectively; the plasma glutamate area under the curve values were 47 ± 28, 191 ± 85, and 358 ± 105 µmol/dl x min, respectively. The data indicate that the plasma glutamate concentration response in 1-yr-old infants ingesting MSG at these glutamate doses is no higher than values observed in adult subjects. © 1986 International Pediatric Research Foundation, Inc.
Details
- Title: Subtitle
- Plasma Glutamate Concentrations in 1-Year-Old Infants and Adults Ingesting Monosodium L-Glutamate in Consommé
- Creators
- Lewis D Stegink - University of IowaL J Filer - University of IowaGeorge L Baker - University of IowaEdward F Bell - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Pediatric research, Vol.20(1), pp.53-58
- DOI
- 10.1203/00006450-198601000-00014
- PMID
- 3945516
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- Language
- English
- Date published
- 01/1986
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984354051802771
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