Plasma Phospholipid Fatty Acids and Coronary Heart Disease Risk: A Matched Case-Control Study within the Women's Health Initiative Observational Study

Qing Liu; Nirupa R Matthan; JoAnn E Manson; Barbara V Howard; Lesley F Tinker; Marian L Neuhouser; Linda V Van Horn; Jacques E Rossouw; Matthew A Allison; Lisa W Martin; Wenjun Li; Linda G Snetselaar; Lu Wang; Alice H Lichtenstein; Charles B Eaton

doi:10.3390/nu11071672

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Plasma Phospholipid Fatty Acids and Coronary Heart Disease Risk: A Matched Case-Control Study within the Women's Health Initiative Observational Study

Journal article

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Plasma Phospholipid Fatty Acids and Coronary Heart Disease Risk: A Matched Case-Control Study within the Women's Health Initiative Observational Study

Qing Liu, Nirupa R Matthan, JoAnn E Manson, Barbara V Howard, Lesley F Tinker, Marian L Neuhouser, Linda V Van Horn, Jacques E Rossouw, Matthew A Allison, Lisa W Martin, …

Nutrients, Vol.11(7), p.1672

07/21/2019

DOI: 10.3390/nu11071672

PMCID: PMC6682955

PMID: 31330892

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Abstract

The association of fatty acids with coronary heart disease (CHD) has been examined, mainly through dietary measurements, and has generated inconsistent results due to measurement error. Large observational studies and randomized controlled trials have shown that plasma phospholipid fatty acids (PL-FA), especially those less likely to be endogenously synthesized, are good biomarkers of dietary fatty acids. Thus, PL-FA profiles may better predict CHD risk with less measurement error. We performed a matched case-control study of 2428 postmenopausal women nested in the Women's Health Initiative Observational Study. Plasma PL-FA were measured using gas chromatography and expressed as molar percentage (moL %). Multivariable conditional logistic regression was used to calculate odds ratios (95% CIs) for CHD associated with 1 moL % change in PL-FA. Higher plasma PL long-chain saturated fatty acids (SFA) were associated with increased CHD risk, while higher n-3 polyunsaturated fatty acids (PUFA) were associated with decreased risk. No significant associations were observed for very-long-chain SFA, monounsaturated fatty acids (MUFA), PUFA n-6 or fatty acids (TFA). Substituting 1 moL % PUFA n-6 or TFA with an equivalent proportion of PUFA n-3 were associated with lower CHD risk. Higher plasma PL long-chain SFA and lower PUFA n-3 were associated with increased CHD risk. A change in diet by limiting foods that are associated with plasma PL long-chain SFA and TFA while enhancing foods high in PUFA n-3 may be beneficial in CHD among postmenopausal women.

Aged

Body Mass Index

Case-Control Studies

Coronary Disease - etiology

Female

Humans

Hyperlipidemias - complications

Middle Aged

Phospholipids - blood

Risk Factors

Details

Title: Subtitle: Plasma Phospholipid Fatty Acids and Coronary Heart Disease Risk: A Matched Case-Control Study within the Women's Health Initiative Observational Study
Creators: Qing Liu - Department of Epidemiology, School of Public Health, Brown University, Providence, RI 02912, USA
Nirupa R Matthan - Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
JoAnn E Manson - Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Barbara V Howard - Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC 20057, USA
Lesley F Tinker - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Marian L Neuhouser - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Linda V Van Horn - Department of Preventive Medicine, Fineberg School of Medicine, Northwest University, 680 N Lake Shore Drive, Suite 1400, Chicago, IL 60611, USA
Jacques E Rossouw - National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
Matthew A Allison - VA San Diego Healthcare System, San Diego, CA 92161, USA
Lisa W Martin - Division of Cardiology, George Washington University School of Medicine and Health Sciences, Washington, DC 20052, USA
Wenjun Li - Health Statistics and Geography Lab, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
Linda G Snetselaar - Department of Epidemiology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
Lu Wang - Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Alice H Lichtenstein - Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Charles B Eaton - Department of Family Medicine, Brown University Alpert Medical School, Providence, RI 02903, USA. cbeaton51@gmail.com
Resource Type: Journal article
Publication Details: Nutrients, Vol.11(7), p.1672
DOI: 10.3390/nu11071672
PMID: 31330892
PMCID: PMC6682955
NLM abbreviation: Nutrients
ISSN: 2072-6643
eISSN: 2072-6643
Grant note: HHSN268201600018C / Women's Health Initiative HHSN268201600003C / Women's Health Initiative HHSN268201600002C / Women's Health Initiative HHSN268201600001C / Women's Health Initiative HHSN268201600004C / Women's Health Initiative
Language: English
Date published: 07/21/2019
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984215140302771

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