Journal article
Plasma Renin Activity during Exercise in the Dog
Circulation research, Vol.38(6), pp.483-487
06/1976
DOI: 10.1161/01.RES.38.6.483
PMID: 1269098
Abstract
Previous workers have suggested that a rise in plasma renin activity (PR A) may mediate some of the hemodynamic changes associated with exercise.To test this hypothesis in nine dogs chronically instrumented for measurement of aortic pressure (catheter) or cardiac output (ascending aorta electromagnetic flow probe) PRA was measured by radioimmunoassay in blood samples drawn before and during running on a level treadmill at 4-8 miles per hour. Exercise caused increases in heart rate from 96 ± 5 (se) to 186 ± 7 beats/ min, cardiac output from 2.8 ± 0.3 to 6.2 ± 0.6 liters/ min, and mean aortic pressure from US ± 5 to 132 ± S mm Hg (P < 0.01). Mean PRA was 6.6 ± 0.7 (se) ng of angiotensin I/ml per 3 hours before and 7.6 ± 1.2 ng Ang 1 during exercise, values that are not different statistically. Propranolol reduced PRA at rest from 8.6 ± 1.1 to 5.9 ± 1.1 ng Ang 1 (P < 0.05), but there was no significant difference between resting and exercise levels, although the increments in heart rate, cardiac output, and mean aortic pressure were reduced. Standing on hindlimbs for 5 minutes did not cause a change in mean aortic pressure or PRA. However, administration of pentolinium reduced mean aortic pressure, and PRA rose from 6.0 ± 1.1 to 9.8 ± 1.5 ng Ang I. Exercise, with or without /3-adrener-gic blockade, does not cause increased PRA in conscious dogs in which the renin-angiotensin system is normally responsive.
Details
- Title: Subtitle
- Plasma Renin Activity during Exercise in the Dog
- Creators
- Meyer Lifschitz - From the Department of Medicine, University of Texas Health Science Center and Audie Murphy Veterans Administration Hospital, San Antonio, TexasLawrence Horwitz
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.38(6), pp.483-487
- Publisher
- American Heart Association, Inc
- DOI
- 10.1161/01.RES.38.6.483
- PMID
- 1269098
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Language
- English
- Date published
- 06/1976
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656529702771
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