Journal article
Plasma Soluble Human Elastin Fragments as an Intra-Aneurysmal Localized Biomarker for Ruptured Intracranial Aneurysm
Journal of the American Heart Association, Vol.7(17), pp.e010051-e010051
09/04/2018
DOI: 10.1161/JAHA.118.010051
PMCID: PMC6201439
PMID: 30371156
Abstract
Background Fragmentation of the tunica media is a hallmark of intracranial aneurysm formation, often leading to aneurysmal progression and subsequent rupture. The objective of this study is to determine the plasma level of elastin fragments in the lumen of ruptured versus unruptured human intracranial aneurysms. Methods and Results One hundred consecutive patients with/without ruptured saccular intracranial aneurysms undergoing endovascular coiling or stent-assisted coiling were recruited. Blood samples were collected from the lumen of intracranial aneurysm using a microcatheter. The tip of the microcatheter was placed inside the aneurysm's sac in close proximity to the inner wall of the dome. Plasma levels of elastin fragments were measured using an ELISA -based method. Mean plasma level of soluble human elastin fragments was significantly greater in ruptured aneurysms when compared with nonruptured aneurysms (102.0±15.5 versus 39.3±9.6 ng/mL; P<0.001). Mean plasma level of soluble human elastin fragments did not have significant correlation with age, sex, size, or aneurysm location. Conclusions The present study revealed that a significantly higher concentration of soluble human elastin fragments in the lumen of ruptured intracranial aneurysms when compared with nonruptured ones.
Details
- Title: Subtitle
- Plasma Soluble Human Elastin Fragments as an Intra-Aneurysmal Localized Biomarker for Ruptured Intracranial Aneurysm
- Creators
- Daichi Nakagawa - 1 Department of Neurosurgery University of Iowa Hospitals and Clinics Iowa City IAMario Zanaty - 1 Department of Neurosurgery University of Iowa Hospitals and Clinics Iowa City IAJoseph Hudson - 1 Department of Neurosurgery University of Iowa Hospitals and Clinics Iowa City IANahom Teferi - 1 Department of Neurosurgery University of Iowa Hospitals and Clinics Iowa City IADaizo Ishii - 4 Department of Neurosurgery Hiroshima University Hiroshima JapanLauren Allan - 2 Department of Surgery University of Iowa Hospitals and Clinics Iowa City IAPascal Jabbour - 5 Department of Neurological Surgery Thomas Jefferson University Hospital Philadelphia PASantiago Ortega-Gutierrez - 3 Department of Neurology, Neurosurgery and Radiology University of Iowa Hospitals and Clinics Iowa City IAEdgar A Samaniego - 3 Department of Neurology, Neurosurgery and Radiology University of Iowa Hospitals and Clinics Iowa City IADavid M Hasan - 1 Department of Neurosurgery University of Iowa Hospitals and Clinics Iowa City IA
- Resource Type
- Journal article
- Publication Details
- Journal of the American Heart Association, Vol.7(17), pp.e010051-e010051
- DOI
- 10.1161/JAHA.118.010051
- PMID
- 30371156
- PMCID
- PMC6201439
- NLM abbreviation
- J Am Heart Assoc
- ISSN
- 2047-9980
- eISSN
- 2047-9980
- Publisher
- England
- Language
- English
- Date published
- 09/04/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Iowa Neuroscience Institute; Surgery; Neurosurgery; Otolaryngology
- Record Identifier
- 9984040277102771
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