Journal article
Plasma alkylresorcinol metabolite, a biomarker of whole-grain wheat and rye intake, and risk of ischemic stroke: a case-control study
The American journal of clinical nutrition, Vol.109(2), pp.1-7
02/01/2019
DOI: 10.1093/ajcn/nqy323
PMID: 30753322
Abstract
Epidemiologic studies on whole grains and risk of stroke have reported inconsistent results, with some suggesting a protective effect but others showing a null association.
The aim of this study was to examine whether plasma 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), a biomarker of whole-grain wheat and rye intake, is associated with risk of ischemic stroke.
A hospital-based case-control study was conducted between March 2011 and May 2016. Cases (n = 990) with first ischemic stroke were matched to controls (n = 990) by sex and age. Concentrations of plasma DHPPA were determined by high-performance liquid chromatography-tandem mass spectrometry. We calculated ORs for the association of plasma DHPPA concentrations with ischemic stroke risk through the use of logistic regression.
Plasma DHPPA was inversely associated with ischemic stroke risk. After adjustment for potential confounding factors, the ORs for ischemic stroke across increasing quartiles of plasma DHPPA concentrations were 1 (referent), 0.76 (95% CI: 0.58, 0.99), 0.71 (95% CI: 0.54, 0.92), and 0.59 (95% CI: 0.45, 0.77), respectively (P-trend = 0.001). The inverse association was also observed in all subgroups of participants according to sex, age, body mass index, smoking status, alcohol consumption, history of hypertension, and history of diabetes.
Our study showed that higher plasma DHPPA concentrations were associated with lower risk of ischemic stroke. This finding provides further evidence to support the health benefits of whole-grain consumption.
Details
- Title: Subtitle
- Plasma alkylresorcinol metabolite, a biomarker of whole-grain wheat and rye intake, and risk of ischemic stroke: a case-control study
- Creators
- Taoping Sun - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaYanwei Zhang - Shenzhen Center for Disease Control and Prevention, Shenzhen, ChinaHao Huang - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaXiaoqian Wang - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaLi Zhou - Shenzhen Center for Disease Control and Prevention, Shenzhen, ChinaShuzhen Li - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaSuli Huang - Shenzhen Center for Disease Control and Prevention, Shenzhen, ChinaChanghui Xie - Shenzhen Center for Disease Control and Prevention, Shenzhen, ChinaYing Wen - Shenzhen Center for Disease Control and Prevention, Shenzhen, ChinaYalun Zhu - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaXiaoli Hu - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaLiangkai Chen - Huazhong University of Science and TechnologyPeiyun Li - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaSijing Chen - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaWei Yang - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaWei Bao - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IAFrank B Hu - Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MAJinquan Cheng - Shenzhen Center for Disease Control and Prevention, Shenzhen, ChinaLiegang Liu - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Resource Type
- Journal article
- Publication Details
- The American journal of clinical nutrition, Vol.109(2), pp.1-7
- Publisher
- United States
- DOI
- 10.1093/ajcn/nqy323
- PMID
- 30753322
- ISSN
- 1938-3207
- eISSN
- 1938-3207
- Grant note
- DOI: 10.13039/501100001809, name: National Natural Science Foundation of China, award: 81573242; DOI: 10.13039/501100012151, name: Sanming Project of Medicine in Shenzhen, award: SZSM201511007; DOI: 10.13039/501100012166, name: National Key Research and Development Program of China, award: 2017YFC1600500; name: Hubei Province of China, award: 2016ACA136
- Language
- English
- Date published
- 02/01/2019
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9983995012802771
Metrics
22 Record Views