Journal article
Plasma and breast-milk selenium in HIV-infected Malawian mothers are positively associated with infant selenium status but are not associated with maternal supplementation: results of the Breastfeeding, Antiretrovirals, and Nutrition study
The American journal of clinical nutrition, Vol.99(4), pp.950-956
04/01/2014
DOI: 10.3945/ajcn.113.073833
PMCID: 3953887
PMID: 24500152
Abstract
Selenium is found in soils and is essential for human antioxidant defense and immune function. In Malawi, low soil selenium and dietary intakes coupled with low plasma selenium concentrations in HIV infection could have negative consequences for the health of HIV-infected mothers and their exclusively breastfed infants.
We tested the effects of lipid-based nutrient supplements (LNS) that contained 1.3 times the Recommended Dietary Allowance of sodium selenite and antiretroviral drugs (ARV) on maternal plasma and breast-milk selenium concentrations.
HIV-infected Malawian mothers in the Breastfeeding, Antiretrovirals, and Nutrition study were randomly assigned at delivery to receive: LNS, ARV, LNS and ARV, or a control. In a subsample of 526 mothers and their uninfected infants, we measured plasma and breast-milk selenium concentrations at 2 or 6 (depending on the availability of infant samples) and 24 wk postpartum.
Overall, mean (± SD) maternal (range: 81.2 ± 20.4 to 86.2 ± 19.9 μg/L) and infant (55.6 ± 16.3 to 61.0 ± 15.4 μg/L) plasma selenium concentrations increased, whereas breast-milk selenium concentrations declined (14.3 ± 11.5 to 9.8 ± 7.3 μg/L) from 2 or 6 to 24 wk postpartum (all P < 0.001). Compared with the highest baseline selenium tertile, low and middle tertiles were positively associated with a change in maternal plasma or breast-milk selenium from 2 or 6 to 24 wk postpartum (both P < 0.001). With the use of linear regression, we showed that LNS that contained selenium and ARV were not associated with changes in maternal plasma and breast-milk selenium, but maternal selenium concentrations were positively associated with infant plasma selenium at 2 or 6 and 24 wk postpartum (P < 0.001) regardless of the study arm.
Selenite supplementation of HIV-infected Malawian women was not associated with a change in their plasma or breast-milk selenium concentrations. Future research should examine effects of more readily incorporated forms of selenium (ie, selenomethionine) in HIV-infected breastfeeding women.
Details
- Title: Subtitle
- Plasma and breast-milk selenium in HIV-infected Malawian mothers are positively associated with infant selenium status but are not associated with maternal supplementation: results of the Breastfeeding, Antiretrovirals, and Nutrition study
- Creators
- Valerie L FlaxMargaret E BentleyGerald F Combs JrCharles S ChaselaDumbani KayiraGerald TeghaDebbie KamwendoEric J DazaAli FokarAthena P KourtisDenise J JamiesonCharles M van der HorstLinda S Adair
- Resource Type
- Journal article
- Publication Details
- The American journal of clinical nutrition, Vol.99(4), pp.950-956
- DOI
- 10.3945/ajcn.113.073833
- PMID
- 24500152
- PMCID
- 3953887
- ISSN
- 0002-9165
- eISSN
- 1938-3207
- Grant note
- R24TW007988 / FIC NIH HHS SIP 22-09 U48-DP001944-01 / NCCDPHP CDC HHS SIP 26-04 U48-DP000059-01 / NCCDPHP CDC HHS P30 AI050410 / NIAID NIH HHS 2-D43 TW001039 / FIC NIH HHS 13-01 U48-CCU409660-09 / PHS HHS P30-AI50410 / NIAID NIH HHS R24 HD050924 / NICHD NIH HHS
- Language
- English
- Date published
- 04/01/2014
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446519002771
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