Journal article
Plasma and urinary clearance rates of atrial natriuretic factor during ontogeny in sheep
Journal of developmental physiology, Vol.10(4), pp.335-346
08/1988
PMID: 2974465
Abstract
The present study was designed to determine the plasma clearance rate of atrial natriuretic factor (ANF) during development in chronically-instrumented fetal, newborn and adult non-pregnant sheep. To determine the contribution of the kidney in the metabolism of ANF, urinary clearance of ANF was also measured. Intravenous infusion of ANF (0.025 and 0.1 microgram.min-1.kg-1) produced a significant decrease in mean arterial blood pressure in newborn lambs and in adult non-pregnant sheep. Estimated plasma ANF clearance rate for the 0.025 and 0.1 microgram.min-1.kg-1 ANF infusion rate were respectively 177 +/- 55 and 155 +/- 34 ml.min-1.kg-1 in fetuses, 138 +/- 26 and 97 +/- 13 ml.min-1.kg-1 in newborn lambs and, 148 +/- 33 and 103 +/- 25 ml.min-1.kg-1 in adult nonpregnant ewes. Fetal, newborn and adult ANF plasma clearance rates during high ANF infusion rate (0.1 microgram.min-1.kg-1) were not significantly different. Low or high ANF infusion rate was not associated with significant changes in urinary ANF concentration or urinary ANF excretion rate. Taken together, the present study demonstrates that ANF plasma clearance rate is similar in fetal, newborn and adult non-pregnant sheep and that the excretory function of the kidney contributes only minimally to ANF plasma clearance rate.
Details
- Title: Subtitle
- Plasma and urinary clearance rates of atrial natriuretic factor during ontogeny in sheep
- Creators
- J E Robillard - Department of Pediatrics, University of Iowa College of Medicine, Iowa City 52242K T NakamuraV A VarilleG P MatherneO J McWeeny
- Resource Type
- Journal article
- Publication Details
- Journal of developmental physiology, Vol.10(4), pp.335-346
- Publisher
- England
- PMID
- 2974465
- ISSN
- 0141-9846
- Grant note
- HL-14388 / NHLBI NIH HHS HL-20576 / NHLBI NIH HHS DK-38302 / NIDDK NIH HHS
- Language
- English
- Date published
- 08/1988
- Academic Unit
- Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Medicine Administration
- Record Identifier
- 9984025597002771
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