Journal article
Plasma cell neoplasms in US solid organ transplant recipients
American journal of transplantation, Vol.13(6), pp.1523-1532
06/2013
DOI: 10.1111/ajt.12234
PMCID: PMC3676887
PMID: 23635036
Abstract
Transplant recipients have elevated risk for plasma cell neoplasms (PCNs, comprising multiple myeloma and plasmacytoma), but little is known about risk factors in the transplant setting. Through linkage of the US solid organ transplant registry with 15 state/regional cancer registries, we identified 140 PCNs in 202 600 recipients (1987-2009). PCN risk was 1.8-fold increased relative to the general population (standardized incidence ratio [SIR] 1.80, 95%CI 1.51-2.12). Among cases, 102 were multiple myeloma (SIR 1.41) and 38 were plasmacytoma (SIR 7.06). PCN incidence increased with age, but due to the rarity of PCNs in younger people in the general population, SIRs were highest in younger transplant recipients (p = 0.03). PCN risk was especially high in recipients who were Epstein-Barr virus (EBV) seronegative at transplantation (SIR 3.93). EBV status was known for 18 tumors, of which 7 (39%) were EBV positive. Following liver transplantation, PCN risk was higher in recipients with cholestatic liver disease (SIR 2.78); five of these cases had primary biliary cirrhosis (PBC). A role for primary EBV infection after transplantation is supported by the increased PCN risk in young EBV seronegative recipients and the presence of EBV in tumors. PBC may be another risk factor, perhaps by causing chronic immune activation.
Details
- Title: Subtitle
- Plasma cell neoplasms in US solid organ transplant recipients
- Creators
- Eric A Engels - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. engelse@exchange.nih.govChristina A ClarkeRuth M PfeifferCharles F LynchDennis D WeisenburgerTodd M GibsonOla LandgrenLindsay M Morton
- Resource Type
- Journal article
- Publication Details
- American journal of transplantation, Vol.13(6), pp.1523-1532
- DOI
- 10.1111/ajt.12234
- PMID
- 23635036
- PMCID
- PMC3676887
- NLM abbreviation
- Am J Transplant
- ISSN
- 1600-6143
- eISSN
- 1600-6143
- Publisher
- United States
- Grant note
- N01PC35142 / NCI NIH HHS 5U58DP000824-04 / NCCDPHP CDC HHS U58DP000832 / NCCDPHP CDC HHS HHSN261201000024C / NCI NIH HHS U58 DP000807 / NCCDPHP CDC HHS U58 DP000824 / NCCDPHP CDC HHS HHSN261201000036C / NCI NIH HHS HHSH234200537009C / PHS HHS N01PC54405 / NCI NIH HHS 5U58DP000812-03 / NCCDPHP CDC HHS U58 DP000817 / NCCDPHP CDC HHS N01PC35137 / NCI NIH HHS 5U58/DP000808-05 / NCCDPHP CDC HHS U58 DP000812 / NCCDPHP CDC HHS 5U58DP000817-05 / NCCDPHP CDC HHS U58 DP000832 / NCCDPHP CDC HHS HHSN261201000035C / NCI NIH HHS HHSH250201000018C / PHS HHS U58 DP000805 / NCCDPHP CDC HHS 15-0351 / PHS HHS 5658DP000805-04 / NCCDPHP CDC HHS N01-PC-35143 / NCI NIH HHS 1U58 DP000807-01 / NCCDPHP CDC HHS U58 DP000848 / NCCDPHP CDC HHS N01-PC-35137 / NCI NIH HHS U58 DP000808 / NCCDPHP CDC HHS HHSN261201000034C / NCI NIH HHS N01-PC-54405 / NCI NIH HHS N01-PC-35142 / NCI NIH HHS N01PC35139 / NCI NIH HHS HHSN261201000037C / NCI NIH HHS N01PC35143 / NCI NIH HHS HHSN261201000027C / NCI NIH HHS ZIA CP010150-13 / Intramural NIH HHS N01-PC-35139 / NCI NIH HHS HHSN261201000026C / NCI NIH HHS U58 DP000848-04 / NCCDPHP CDC HHS HHSN261201000035I / NCI NIH HHS
- Language
- English
- Date published
- 06/2013
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995159002771
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