Journal article
Plasma clozapine concentrations as a predictor of clinical response: a follow-up study
The journal of clinical psychiatry, Vol.55 Suppl B(9), pp.117-121
09/1994
PMID: 7961554
Abstract
We investigated the relationship between plasma clozapine concentrations and clinical response in treatment-refractory schizophrenic patients. In a previous study, we found that plasma drug concentrations above 350 ng/mL maximized clinical response in a group of 29 patients. This study represents a follow-up of these original 29 patients over approximately 2 1/2 years of clozapine treatment. We found that during the initial 6-week trial of clozapine, 38% (N = 11) of the patients were considered to be responders. With continued treatment, we found that 58% (14 of 24) were classified as responders. Consistent with our previous study, we observed that plasma concentrations were helpful in predicting response. Five of 7 patients who had unsatisfactory response became responders when their plasma clozapine concentrations increased to above 350 ng/mL. We conclude that the assessment of plasma clozapine concentrations as a guide to dose adjustment may be useful in maximizing response.
Details
- Title: Subtitle
- Plasma clozapine concentrations as a predictor of clinical response: a follow-up study
- Creators
- D D Miller - Mental Health Clinical Research Center, University of Iowa Hospital and Clinic 52242F FlemingT L HolmanP J Perry
- Resource Type
- Journal article
- Publication Details
- The journal of clinical psychiatry, Vol.55 Suppl B(9), pp.117-121
- Publisher
- United States
- PMID
- 7961554
- ISSN
- 0160-6689
- eISSN
- 1555-2101
- Grant note
- MH-43271 / NIMH NIH HHS
- Language
- English
- Date published
- 09/1994
- Academic Unit
- Pharmacy; Psychiatry
- Record Identifier
- 9984003943602771
Metrics
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