Plasma concentration of trimethylamine-N-oxide and risk of gestational diabetes mellitus

Peiyun Li; Chunrong Zhong; Shuzhen Li; Taoping Sun; Hao Huang; Xi Chen; Yalun Zhu; Xiaoli Hu; Xiaobo Peng; Xu Zhang; Wei Bao; Zhilei Shan; Jinquan Cheng; Frank B Hu; Nianhong Yang; Liegang Liu

doi:10.1093/ajcn/nqy116

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Plasma concentration of trimethylamine-N-oxide and risk of gestational diabetes mellitus

Journal article

Open access

Peer reviewed

Plasma concentration of trimethylamine-N-oxide and risk of gestational diabetes mellitus

Peiyun Li, Chunrong Zhong, Shuzhen Li, Taoping Sun, Hao Huang, Xi Chen, Yalun Zhu, Xiaoli Hu, Xiaobo Peng, Xu Zhang, …

The American journal of clinical nutrition, Vol.108(3), pp.603-610

09/01/2018

DOI: 10.1093/ajcn/nqy116

PMCID: PMC6924263

PMID: 30535087

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Abstract

The microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) has been reported as a novel and independent risk factor for the development of cardiovascular and metabolic diseases, but the association with gestational diabetes mellitus (GDM) remains unclear. The aim of this study was to investigate the association between plasma TMAO concentration and GDM in a 2-phase study. A 2-phase design was used in the current study. An initial phase included 866 participants (433 GDM cases and 433 matched controls) with fasting blood samples collected at the time of GDM screening (24-32 wk of gestation). An independent-phase study, with 276 GDM cases and 552 matched controls who provided fasting blood samples before 20 wk of gestation and who had GDM screened during 24-32 wk of gestation, was nested within a prospective cohort study. These 2 studies were both conducted in Wuhan, China, and the incidence of GDM in the cohort study was 10.8%. Plasma TMAO concentrations were determined by stable isotope dilution liquid chromatography-tandem mass spectrometry. GDM was diagnosed according to the American Diabetes Association criteria by using an oral-glucose-tolerance test. In the initial case-control study, the adjusted OR of GDM comparing the highest TMAO quartile with the lowest quartile was 1.94 (95% CI: 1.28, 2.93). Each SD increment of ln-transformed plasma TMAO was associated with 22% (95% CI: 5%, 41%) higher odds of GDM. In the nested case-control study, women in the highest quartile also had increased odds of GDM (adjusted OR: 2.06; 95% CI: 1.28, 3.31) compared with women in the lowest quartile, and the adjusted OR for GDM per SD increment of ln-transformed plasma TMAO was 1.26 (95% CI: 1.08, 1.47). Consistent findings from this 2-phase study indicate a positive association between plasma TMAO concentrations and GDM. Future studies are warranted to elucidate the underlying mechanisms. This trial was registered at www.clinicaltrials.gov as NCT03415295.

Pregnancy

Diabetes, Gestational - blood

Glucose Tolerance Test

Fasting

Prospective Studies

Humans

Risk Factors

Methylamines - blood

Gestational Age

Case-Control Studies

Adult

Female

Odds Ratio

Cohort Studies

Details

Title: Subtitle: Plasma concentration of trimethylamine-N-oxide and risk of gestational diabetes mellitus
Creators: Peiyun Li - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Chunrong Zhong - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Shuzhen Li - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Taoping Sun - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Hao Huang - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Xi Chen - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Yalun Zhu - Huazhong University of Science and Technology
Xiaoli Hu - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Xiaobo Peng - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Xu Zhang - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Wei Bao - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA
Zhilei Shan - Departments of Nutrition
Jinquan Cheng - Shenzhen Center for Disease Control and Prevention, Shenzhen, China
Frank B Hu - Epidemiology, Harvard TH Chan School of Public Health, Boston, MA
Nianhong Yang - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Liegang Liu - Huazhong University of Science and Technology
Resource Type: Journal article
Publication Details: The American journal of clinical nutrition, Vol.108(3), pp.603-610
Publisher: United States
DOI: 10.1093/ajcn/nqy116
PMID: 30535087
PMCID: PMC6924263
ISSN: 1938-3207
eISSN: 1938-3207
Grant note: R21 HD091458 / NICHD NIH HHS
Language: English
Date published: 09/01/2018
Academic Unit: Preventive and Community Dentistry; Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9983995179202771

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