Journal article
Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study
Journal of diabetes, Vol.10(6), pp.487-495
06/2018
DOI: 10.1111/1753-0407.12563
PMCID: PMC5837900
PMID: 28436169
Abstract
Abnormal lipid profiles have been associated with gestational diabetes mellitus (GDM), but studies with longitudinal measures of lipids throughout pregnancy are sparse. The aim of the present study was to characterize longitudinal changes in lipid profiles throughout pregnancy and prospectively examine the associations of plasma lipid concentrations with risk of GDM.
This study was a nested case-control study including 107 GDM cases and 214 matched non-GDM controls from participants in the National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies - Singleton cohort. Blood samples were collected longitudinally at Gestational Weeks (GW) 10-14, 15-26 (fasting sample), 23-31, and 33-39. Plasma concentrations of triglycerides, total cholesterol, and high-density lipoprotein cholesterol (HDL-C) were measured by enzymatic assays. Low-density lipoprotein cholesterol (LDL-C) was calculated using Friedewald's formula.
Plasma triglycerides, total cholesterol, and LDL-C increased as pregnancy progressed. At GW 10-14, the adjusted odds ratios (aORs) of GDM comparing the highest versus lowest quartile were 3.15 (95% confidence interval [CI] 1.38-7.15; P
= 0.002) for triglycerides and 0.44 (95% CI 0.18-1.09; P
= 0.045) for HDL-C. At GW 15-26, the aORs were 6.57 (95% CI 2.25-19.17; P
= 0.001) for triglycerides and 0.23 (95% CI 0.08-0.63; P
= 0.005) for HDL-C. No significant associations were observed for total cholesterol and LDL-C concentrations with risk of GDM.
Higher plasma triglyceride and lower HDL-C concentrations in early and mid-pregnancy were significantly associated with a greater risk of GDM. Total cholesterol and LDL-C concentrations during pregnancy were not significantly associated with GDM risk.
Details
- Title: Subtitle
- Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study
- Creators
- Wei Bao - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USASharon Dar - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USAYeyi Zhu - Division of Research, Kaiser Permanente Northern California, Oakland, California, USAJing Wu - Glotech Inc., Rockville, Maryland, USAShristi Rawal - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USAShanshan Li - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USANatalie L Weir - Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USAMichael Y Tsai - Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USACuilin Zhang - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
- Resource Type
- Journal article
- Publication Details
- Journal of diabetes, Vol.10(6), pp.487-495
- DOI
- 10.1111/1753-0407.12563
- PMID
- 28436169
- PMCID
- PMC5837900
- NLM abbreviation
- J Diabetes
- ISSN
- 1753-0407
- eISSN
- 1753-0407
- Publisher
- Australia
- Grant note
- HHSN275200800012C / NICHD NIH HHS P30 ES005605 / NIEHS NIH HHS HHSN275200800013C / NICHD NIH HHS HHSN275200800014C / NICHD NIH HHS HHSN275200800028C / NICHD NIH HHS HHSN275201000009C / NICHD NIH HHS HHSN275201000001G / NICHD NIH HHS HHSN275201000001Z / NICHD NIH HHS HHSN275200800002I / NICHD NIH HHS HHSN275200800002C / NICHD NIH HHS HHSN275200800003C / NICHD NIH HHS HHSN275200800003I / NICHD NIH HHS
- Language
- English
- Date published
- 06/2018
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9983995133602771
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