Plasma heme oxygenase-1 concentration in relation to impaired glucose regulation in a non-diabetic Chinese population

Wei Bao; Shuang Rong; Muxun Zhang; Xuefeng Yu; Yanting Zhao; Xiao Xiao; Wei Yang; Di Wang; Ping Yao; Frank B Hu; Liegang Liu

doi:10.1371/journal.pone.0032223

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Plasma heme oxygenase-1 concentration in relation to impaired glucose regulation in a non-diabetic Chinese population

Journal article

Open access

Peer reviewed

Plasma heme oxygenase-1 concentration in relation to impaired glucose regulation in a non-diabetic Chinese population

Wei Bao, Shuang Rong, Muxun Zhang, Xuefeng Yu, Yanting Zhao, Xiao Xiao, Wei Yang, Di Wang, Ping Yao, Frank B Hu, …

PloS one, Vol.7(3), pp.e32223-e32223

2012

DOI: 10.1371/journal.pone.0032223

PMCID: PMC3299661

PMID: 22427825

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Abstract

Our previous study has recently shown that plasma heme oxygenase-1 (HO-1), a stress-responsive protein, is elevated in individuals with type 2 diabetes. The current study aimed to examine the association between plasma HO-1 concentration and impaired glucose regulation (IGR) in non-diabetic individuals. We conducted a case-control study including a total of 865 subjects (262 IGR individuals and 603 healthy controls) in a Chinese population. Basic characteristics were collected by questionnaire and standardized anthropometric measurements. Plasma HO-1 concentration was determined by ELISA. Plasma HO-1 concentration was significantly increased in IGR individuals compared with healthy controls (1.34 (0.81-2.29) ng/ml vs 0.98 (0.56-1.55) ng/ml, P<0.001). After adjustment for age, sex, and BMI, the ORs for IGR in the highest quartile of plasma HO-1 concentrations, compared with the lowest, was 3.42 (95% CI 2.11-5.54; P for trend <0.001). The trend remained significant even after additional adjustment for smoking, alcohol drinking, hypertension, family history of diabetes, lipid profiles and C-reactive protein. In the receiver-operating characteristic curve analysis, addition of plasma HO-1 concentration to a model with known risk factors yielded significantly improved discriminative value for IGR (area under the curves 0.75 (95% CI 0.71-0.78) vs. 0.72 (95% CI 0.69-0.76); P for difference = 0.026). Elevated plasma HO-1 concentration is significantly associated with increased ORs for IGR. However, its clinical utility should be validated in further studies, especially in prospective cohort studies.

Heme Oxygenase-1 - blood

Asian Continental Ancestry Group

Enzyme-Linked Immunosorbent Assay

Area Under Curve

Humans

Statistics, Nonparametric

Logistic Models

ROC Curve

C-Reactive Protein - analysis

Case-Control Studies

Glucose Intolerance - blood

Details

Title: Subtitle: Plasma heme oxygenase-1 concentration in relation to impaired glucose regulation in a non-diabetic Chinese population
Creators: Wei Bao - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Shuang Rong
Muxun Zhang
Xuefeng Yu
Yanting Zhao
Xiao Xiao - Huazhong University of Science and Technology
Wei Yang
Di Wang
Ping Yao
Frank B Hu
Liegang Liu
Resource Type: Journal article
Publication Details: PloS one, Vol.7(3), pp.e32223-e32223
DOI: 10.1371/journal.pone.0032223
PMID: 22427825
PMCID: PMC3299661
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Publisher: United States
Language: English
Date published: 2012
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9983995125202771

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