Plasma heme oxygenase-1 concentration is elevated in individuals with type 2 diabetes mellitus

Wei Bao; Fangfang Song; Xiangyang Li; Shuang Rong; Wei Yang; Muxun Zhang; Ping Yao; Liping Hao; Nianhong Yang; Frank B Hu; Liegang Liu

doi:10.1371/journal.pone.0012371

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Plasma heme oxygenase-1 concentration is elevated in individuals with type 2 diabetes mellitus

Journal article

Open access

Peer reviewed

Plasma heme oxygenase-1 concentration is elevated in individuals with type 2 diabetes mellitus

Wei Bao, Fangfang Song, Xiangyang Li, Shuang Rong, Wei Yang, Muxun Zhang, Ping Yao, Liping Hao, Nianhong Yang, Frank B Hu, …

PloS one, Vol.5(8), pp.e12371-e12371

08/25/2010

DOI: 10.1371/journal.pone.0012371

PMCID: PMC2928270

PMID: 20811623

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Abstract

Circulating concentrations of heme oxygenase-1 (HO-1) have been recently reported to be elevated in several chronic disorders. However, no study has ever examined the association between circulating HO-1 concentrations and type 2 diabetes mellitus (T2DM). 581 cases with newly-diagnosed T2DM (New-T2DM) and 611 comparison controls were recruited in this two-phase case-control study, comprising 420 cases and 429 controls collected in the first phase study and 161 cases and 182 controls in the second phase replication study. Analyses, using both separated data and combined data from the two-phase studies, show that plasma HO-1 concentrations were significantly increased in New-T2DM cases compared to controls (P<0.001). Plasma HO-1 concentrations were significantly correlated with plasma glucose concentrations, HOMA-beta and HOMA-IR (P<0.001). After adjustment for age, sex, BMI and family history of diabetes, the ORs for New-T2DM in the highest quartile of plasma HO-1 concentrations, compared with the lowest, was 8.23 (95% CI 5.55-12.21; P for trend <0.001). The trend remained significant after additional adjustment for fasting plasma glucose/insulin, HOMA-beta/HOMA-IR, TC/TG, smoking, drinking and history of hypertension, and even in further stratification analysis by age, sex, BMI, smoking, drinking and history of hypertension. Elevated plasma HO-1 concentrations are associated with higher ORs for New-T2DM, which add more knowledge regarding the important role of oxidative stress in T2DM. More consequent studies were warranted to confirm the clinical utility of plasma HO-1, especially in diagnosis and prognosis of T2DM and its complications.

Body Mass Index

Heme Oxygenase-1 - blood

Age Factors

Humans

Middle Aged

Diabetes Mellitus, Type 2 - enzymology

Male

Case-Control Studies

Diabetes Mellitus, Type 2 - diagnosis

Diabetes Mellitus, Type 2 - blood

Diabetes Mellitus, Type 2 - physiopathology

Analysis of Variance

Sex Factors

Female

Details

Title: Subtitle: Plasma heme oxygenase-1 concentration is elevated in individuals with type 2 diabetes mellitus
Creators: Wei Bao - Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Fangfang Song
Xiangyang Li - Huazhong University of Science and Technology
Shuang Rong
Wei Yang
Muxun Zhang
Ping Yao
Liping Hao
Nianhong Yang
Frank B Hu
Liegang Liu
Resource Type: Journal article
Publication Details: PloS one, Vol.5(8), pp.e12371-e12371
DOI: 10.1371/journal.pone.0012371
PMID: 20811623
PMCID: PMC2928270
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Publisher: Public Library of Science; United States
Language: English
Date published: 08/25/2010
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9983996196402771

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