Journal article
Plasma proteins related to inflammatory diet predict future cognitive impairment
Molecular psychiatry, Vol.28(4), pp.1599-1609
04/2023
DOI: 10.1038/s41380-023-01975-7
PMCID: PMC10208977
PMID: 36737481
Abstract
Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the development of cognitive impairment in aging are not well understood. To determine whether plasma proteins linked to inflammatory diet predict future cognitive impairment, we applied high-throughput proteomic assays to plasma samples from a subset (n = 1528) of Women's Health Initiative Memory Study (WHIMS) participants (mean [SD] baseline age, 71.3 [SD 3.8] years). Results provide insights into how inflammatory nutritional patterns are associated with an immune-related proteome and identify a group of proteins (CXCL10, CCL3, HGF, OPG, CDCP1, NFATC3, ITGA11) related to future cognitive impairment over a 14-year follow-up period. Several of these inflammatory diet proteins were also associated with dementia risk across two external cohorts (ARIC, ESTHER), correlated with plasma biomarkers of Alzheimer's disease (AD) pathology (Aβ
) and/or neurodegeneration (NfL), and related to an MRI-defined index of neurodegenerative brain atrophy in a separate cohort (BLSA). In addition to evaluating their biological relevance, assessing their potential role in AD, and characterizing their immune-tissue/cell-specific expression, we leveraged published RNA-seq results to examine how the in vitro regulation of genes encoding these candidate proteins might be altered in response to an immune challenge. Our findings indicate how dietary patterns with higher inflammatory potential relate to plasma levels of immunologically relevant proteins and highlight the molecular mediators which predict subsequent risk for age-related cognitive impairment.
Details
- Title: Subtitle
- Plasma proteins related to inflammatory diet predict future cognitive impairment
- Creators
- Michael R Duggan - National Institute on AgingLauren Butler - National Institute on AgingZhongsheng Peng - National Institute on AgingGulzar N Daya - National Institute on AgingAbhay Moghekar - Johns Hopkins University School of MedicineYang An - National Institute on AgingStephen R Rapp - Wake Forest UniversityKathleen M Hayden - Wake Forest UniversityAladdin H Shadyab - University of California San DiegoGinny Natale - Stony Brook UniversityLongjian Liu - Drexel UniversityLinda Snetselaar - University of IowaRuin Moaddel - National Institute on AgingCasey M Rebholz - Johns Hopkins UniversityKevin Sullivan - University of Mississippi Medical CenterChristie M Ballantyne - Baylor College of MedicineSusan M Resnick - National Institute on AgingLuigi Ferrucci - National Institute on AgingKeenan A Walker - National Institute on Aging
- Resource Type
- Journal article
- Publication Details
- Molecular psychiatry, Vol.28(4), pp.1599-1609
- DOI
- 10.1038/s41380-023-01975-7
- PMID
- 36737481
- PMCID
- PMC10208977
- NLM abbreviation
- Mol Psychiatry
- ISSN
- 1359-4184
- eISSN
- 1476-5578
- Grant note
- R01-AG049953 / U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01-HL134320 / U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) 200-2011-39361 / U.S. Department of Health & Human Services | Centers for Disease Control and Prevention (CDC)
- Language
- English
- Electronic publication date
- 02/03/2023
- Date published
- 04/2023
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984365058302771
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