Plasma sphingomyelin and longitudinal change in percent emphysema on CT. The MESA Lung study

Firas S Ahmed; Xian-cheng Jiang; Joseph E Schwartz; Eric A Hoffman; Joseph Yeboah; Steven Shea; Kristin Marie Burkart; R. Graham Barr

doi:10.3109/1354750X.2014.896414

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Plasma sphingomyelin and longitudinal change in percent emphysema on CT. The MESA Lung study

Journal article

Peer reviewed

Plasma sphingomyelin and longitudinal change in percent emphysema on CT. The MESA Lung study

Firas S Ahmed, Xian-cheng Jiang, Joseph E Schwartz, Eric A Hoffman, Joseph Yeboah, Steven Shea, Kristin Marie Burkart and R. Graham Barr

Biomarkers, Vol.19(3), pp.207-213

05/01/2014

DOI: 10.3109/1354750X.2014.896414

PMID: 24649875

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Abstract

Context: Ceramide causes endothelial apoptosis and emphysema-like changes in animal models. Objectives: Test if plasma sphingomyelin, a major precursor of ceramide, would predict longitudinal increase in the percentage of emphysema-like lung on computed tomography (CT). Materials and methods: 3840 participants had their plasma sphingomyelin measured at baseline examination and their pulmonary emphysema measured on cardiac CT scans at baseline and on follow-up visits. Mixed effects models were used to adjust for potential confounders. Results: One standard deviation increase in sphingomyelin predicted a 0.12% per year (95% CI: 0.02-0.22; p = 0.019) greater increase of percent emphysema. Discussion and conclusion: Higher plasma levels of sphingomyelin predicted greater annual increase in quantitatively measured percent emphysema.

Computed Tomography

Ceramide

sphingomyelin

emphysema

Details

Title: Subtitle: Plasma sphingomyelin and longitudinal change in percent emphysema on CT. The MESA Lung study
Creators: Firas S Ahmed - Department of Radiology, College of Physicians and Surgeons, Columbia University
Xian-cheng Jiang - Department of Cell Biology, Downstate Medical Center, State University of New York
Joseph E Schwartz - Center for Behavioral Cardiovascular Health, College of Physicians and Surgeons, Columbia University
Eric A Hoffman - Department of Radiology, Carver School of Medicine, University of Iowa
Joseph Yeboah - Division of Cardiology, School of Medicine, Wake Forest University Baptist Health
Steven Shea - Department of Epidemiology, Mailman School of Public Health, Columbia University
Kristin Marie Burkart - Department of Medicine
R. Graham Barr - Department of Epidemiology, Mailman School of Public Health, Columbia University
Resource Type: Journal article
Publication Details: Biomarkers, Vol.19(3), pp.207-213
DOI: 10.3109/1354750X.2014.896414
PMID: 24649875
NLM abbreviation: Biomarkers
ISSN: 1354-750X
eISSN: 1366-5804
Publisher: Taylor & Francis
Language: English
Date published: 05/01/2014
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984051891602771

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