Journal article
Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells
The Journal of immunology (1950), Vol.184(8), pp.4440-4446
04/15/2010
DOI: 10.4049/jimmunol.0902984
PMCID: PMC2851488
PMID: 20220091
Abstract
Previous studies have shown that the reduction in CD8 T cell immunity observed during high-dose influenza virus infection (IAV) is mediated via lymph node (LN) dendritic cells (DC) that express FasL and drive FasL:Fas (DC:T) induced apoptosis. However, the specific DC subset(s) within the LN and the additional factors required for DC-mediated elimination of IAV-specific CD8 T cells remain unknown. Herein, we demonstrate that plasmacytoid DC (pDC) which downregulate FasL during sublethal, but not lethal, IAV-infection accumulate to greater numbers within the LN of lethal dose infected mice. Further our findings show that pDC from lethal, but not sublethal dose IAV infections, drive elimination of Fas
+
CD8 T cells and that this elimination only occurs in the absence of TCR recognition of IAV-peptide-MHC class I complexes. Together these results suggest that pDC play a heretofore unknown deleterious role during lethal dose IAV-infections by limiting the CD8 T cell response.
Details
- Title: Subtitle
- Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells
- Creators
- Ryan A Langlois - Department of Pathology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, United StatesKevin L Legge - Department of Pathology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.184(8), pp.4440-4446
- DOI
- 10.4049/jimmunol.0902984
- PMID
- 20220091
- PMCID
- PMC2851488
- NLM abbreviation
- J Immunol
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Language
- English
- Date published
- 04/15/2010
- Academic Unit
- Microbiology and Immunology; Pathology
- Record Identifier
- 9984047989302771
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