Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor

Hsiangkuo Yuan; Christy M. Wilson; Jun Xia; Sarah L. Doyle; Shuqin Li; Andrew M. Fales; Yang Liu; Ema Ozaki; Kelly Mulfaul; Gabi Hanna; Gregory M. Palmer; Lihong V. Wang; Gerald A. Grant; Tuan Vo-Dinh

doi:10.1039/c3nr06770j

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Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor

Journal article

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Peer reviewed

Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor

Hsiangkuo Yuan, Christy M. Wilson, Jun Xia, Sarah L. Doyle, Shuqin Li, Andrew M. Fales, Yang Liu, Ema Ozaki, Kelly Mulfaul, Gabi Hanna, …

Nanoscale, Vol.6(8), pp.4078-4082

04/21/2014

DOI: 10.1039/c3nr06770j

PMCID: PMC4343032

PMID: 24619405

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https://www.ncbi.nlm.nih.gov/pmc/articles/4343032View

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Abstract

Plasmonics-active gold nanostars exhibiting strong imaging contrast and efficient photothermal transduction were synthesized for a novel pulsed laser-modulated plasmonics-enhanced brain tumor microvascular permeabilization. We demonstrate a selective, optically modulated delivery of nanoprobes into the tumor parenchyma with minimal off-target distribution.

Materials Science

Physical Sciences

Physics

Technology

Chemistry

Chemistry, Multidisciplinary

Materials Science, Multidisciplinary

Nanoscience & Nanotechnology

Physics, Applied

Science & Technology

Science & Technology - Other Topics

Details

Title: Subtitle: Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor
Creators: Hsiangkuo Yuan - Duke University
Christy M. Wilson - Duke Medical Center
Jun Xia - Washington University in St. Louis
Sarah L. Doyle - Trinity College Dublin
Shuqin Li - Duke University Hospital
Andrew M. Fales - Duke University
Yang Liu - Duke University
Ema Ozaki - Trinity College Dublin
Kelly Mulfaul - National Children’s Research Centre
Gabi Hanna - Duke Medical Center
Gregory M. Palmer - Duke Medical Center
Lihong V. Wang - Washington University in St. Louis
Gerald A. Grant - Duke University Hospital
Tuan Vo-Dinh - Duke University
Resource Type: Journal article
Publication Details: Nanoscale, Vol.6(8), pp.4078-4082
DOI: 10.1039/c3nr06770j
PMID: 24619405
PMCID: PMC4343032
NLM abbreviation: Nanoscale
ISSN: 2040-3364
eISSN: 2040-3372
Publisher: Royal Soc Chemistry
Number of pages: 5
Grant note: HR0011-13-2-0003 / Defense Advanced Research Projects Agency; United States Department of Defense; Defense Advanced Research Projects Agency (DARPA) Duke Exploratory Research Funds P30CA014236 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) K08NS075144 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01 EB006201; T32 EB001040; 5K08-NS075144-03; DP1 EB016986; R01 EB016963 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA W81XWH-09-1-0064 / Department of Defense (DOD); United States Department of Defense R01EB006201 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) National Children's Research Centre (NCRC) Funds
Language: English
Date published: 04/21/2014
Academic Unit: Iowa Neuroscience Institute; Neuroscience and Pharmacology
Record Identifier: 9984771653402771

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