Journal article
Plasticity of Cerebral Microvascular Structure and Mechanics During Hypertension and Following Recovery of Arterial Pressure
American journal of physiology. Heart and circulatory physiology, Vol.323(6), pp.H1108-H1117
10/21/2022
DOI: 10.1152/ajpheart.00292.2022
PMCID: PMC9678426
PMID: 36269650
Abstract
Changes in vascular structure contribute to vascular events and loss of brain health. We examined changes in cerebral arterioles at the onset of hypertension and the hypothesis that alterations during hypertension would recover with the return of mean arterial pressure (MAP) to normal. MAP was measured with radiotelemetry in awake male C57BL/6J mice at baseline and during infusion of vehicle or angiotensin II (ANG II, 1.4 mg/kg/day using osmotic pumps) for 28 days, followed by a 28-day recovery. With ANG II treatment, MAP increased through day 28. On day 30, MAP began to recover, reaching levels not different from vehicle on day 37. We measured intravascular pressure, diameter, wall thickness (WT), wall:lumen ratio (W:L), cross-sectional area (CSA), and slope of the tangential elastic modulus (ET) in maximally dilated arterioles. Variables were similar in both groups at day 1, with no significant change with vehicle treatment. With ANG II treatment, CSA, WT, and W:L increased on days 7-28. Internal and external diameter was reduced at 14 and 28 days. ET versus wall stress was reduced on days 7-28. During recovery, the diameter remained at days 14 and 28 values, whereas other variables returned partly or completely to normal. Thus, CSA, WT, W: L, and ET versus wall stress changed rapidly during hypertension and recovered with MAP. In contrast, inward remodeling developed slowly and did not recover. This lack of recovery has mechanistic implications for the long-term impact of hypertension on vascular determinants of brain health. NEW & NOTEWORTHY Changes in vascular structure contribute to vascular events and loss of brain health. We examined the inherent structural plasticity of cerebral arterioles during and after a period of hypertension. Arteriolar wall thickness, diameter, wall-to-lumen ratio, and biological stiffness changed rapidly during hypertension and recovered with blood pressure. In contrast, inward remodeling developed slowly and did not recover. This lack of recovery of arteriolar diameter has implications for the long-term impact of hypertension on vascular determinants of brain health.
Details
- Title: Subtitle
- Plasticity of Cerebral Microvascular Structure and Mechanics During Hypertension and Following Recovery of Arterial Pressure
- Creators
- Rasna Sabharwal - Roy J. and Lucille A. Carver College of MedicineMark W Chapleau - Roy J. and Lucille A. Carver College of MedicineThomas D Gerhold - Roy J. and Lucille A. Carver College of MedicineGary L Baumbach - Roy J. and Lucille A. Carver College of MedicineFrank M Faraci - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Heart and circulatory physiology, Vol.323(6), pp.H1108-H1117
- DOI
- 10.1152/ajpheart.00292.2022
- PMID
- 36269650
- PMCID
- PMC9678426
- ISSN
- 0363-6135
- eISSN
- 1522-1539
- Grant note
- DOI: 10.13039/100000050, name: HHS | NIH | National Heart, Lung, and Blood Institute, award: HL014388; DOI: 10.13039/100000050, name: HHS | NIH | National Heart, Lung, and Blood Institute, award: HL149677; DOI: 10.13039/100000065, name: HHS | NIH | National Institute of Neurological Disorders and Stroke, award: NS096465; DOI: 10.13039/100000065, name: HHS | NIH | National Institute of Neurological Disorders and Stroke, award: NS108409; DOI: 10.13039/100000065, name: HHS | NIH | National Institute of Neurological Disorders and Stroke, award: NS072628; DOI: 10.13039/100000049, name: HHS | NIH | National Institute on Aging, award: AG070188; DOI: 10.13039/501100001674, name: Fondation Leducq, award: Transatlantic CVD 01
- Language
- English
- Date published
- 10/21/2022
- Academic Unit
- Molecular Physiology and Biophysics; Pathology; Iowa Neuroscience Institute; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984306659002771
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