Journal article
Platelet-Mediated Modulation of Adaptive Immunity: A Communication Link between Innate and Adaptive Immune Compartments
Immunity (Cambridge, Mass.), Vol.19(1), pp.9-19
2003
DOI: 10.1016/S1074-7613(03)00177-8
PMID: 12871635
Abstract
Platelets are highly reactive components of the circulatory system with well-documented hemostatic function. Recent studies extend platelet function to modulation of local inflammatory events through the release of chemokines, cytokines, and a number of immunomodulatory ligands, including CD154. We hypothesized that platelet-derived CD154 modulates adaptive immunity. The data reported herein demonstrate that platelets, via CD154, induce dendritic cell maturation, B cell isotype switching, and augment CD8
+ T cell responses both in vitro and in vivo. Platelet transfusion studies demonstrate that platelet-derived CD154 alone is sufficient to induce isotype switching and augment T lymphocyte function during viral infection, leading to enhanced protection against viral rechallenge. Additionally, depletion of platelets in normal mice results in decreased antigen-specific antibody production.
Details
- Title: Subtitle
- Platelet-Mediated Modulation of Adaptive Immunity: A Communication Link between Innate and Adaptive Immune Compartments
- Creators
- Bennett D Elzey - The University of Iowa Department of Urology, Iowa City, IA 52242 USAJun Tian - The University of Iowa Department of Urology, Iowa City, IA 52242 USARobert J Jensen - The University of Iowa Department of Urology, Iowa City, IA 52242 USAAxel K Swanson - The University of Iowa Department of Urology, Iowa City, IA 52242 USAJason R Lees - The University of Iowa Department of Urology, Iowa City, IA 52242 USASteven R Lentz - Iowa City Veterans Affairs Medical Center, Iowa City, IA 52242 USAColleen S Stein - The University of Iowa Department of Internal Medicine, Iowa City, IA 52242 USABernhard Nieswandt - Rudolf Virchow Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, GermanyYiqiang Wang - The University of Iowa Department of Urology, Iowa City, IA 52242 USABeverly L Davidson - The University of Iowa Department of Internal Medicine, Iowa City, IA 52242 USATimothy L Ratliff - The University of Iowa Department of Urology, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Immunity (Cambridge, Mass.), Vol.19(1), pp.9-19
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S1074-7613(03)00177-8
- PMID
- 12871635
- ISSN
- 1074-7613
- eISSN
- 1097-4180
- Language
- English
- Date published
- 2003
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Urology; Internal Medicine
- Record Identifier
- 9984094317202771
Metrics
22 Record Views