Journal article
Platelet-derived growth factor applications in periodontal and peri-implant bone regeneration
Expert opinion on biological therapy, Vol.11(3), pp.375-385
03/2011
DOI: 10.1517/14712598.2011.554814
PMCID: PMC3056074
PMID: 21288185
Abstract
Introduction:\nAchieving successful tissue regeneration following traditional therapeutic protocols, combining bone grafts and barrier membranes, may be challenging in certain clinical scenarios. A deeper understanding of periodontal and peri-implant wound healing and recent advances in the field of tissue engineering have provided clinicians with novel means to obtain predictable clinical outcomes. The use of growth factors such as recombinant human platelet-derived growth factor-BB (rhPDGF) with biocompatible matrices to promote tissue regeneration represents a promising approach in the disciplines of periodontology and implantology.\nAreas covered:\nThis review covers the basic principles of bone and periodontal regeneration, and provides an overview of the biology of PDGF and its potential to predictably and reproducibly promote bone regeneration in regular clinical practice. The results of preclinical and clinical human studies evaluating the effectiveness of growth-factor-enhanced matrices are analyzed and discussed.\nExpert opinion:\nCurrent available evidence supports the use of rhPDGF-enhanced matrices to promote periodontal and peri-implant bone regeneration.
Details
- Title: Subtitle
- Platelet-derived growth factor applications in periodontal and peri-implant bone regeneration
- Creators
- Darnell Kaigler - 1University of Michigan School of Dentistry, Department of Periodontics and Oral Medicine and Michigan Center for Oral Health Research, 1011 North University Avenue, Ann Arbor, MI 48109 1078, USA william.giannobile@umich.eduGustavo Avila - 1University of Michigan School of Dentistry, Department of Periodontics and Oral Medicine and Michigan Center for Oral Health Research, 1011 North University Avenue, Ann Arbor, MI 48109 1078, USA william.giannobile@umich.eduLeslie Wisner-Lynch - 3Biomimetic Therapeutics, Inc., Franklin, TN, USAMarc L Nevins - 4Harvard School of Dental Medicine, Division of Periodontology, Department of Oral Medicine, Infection and Immunity, Boston, MA, USAMyron Nevins - 4Harvard School of Dental Medicine, Division of Periodontology, Department of Oral Medicine, Infection and Immunity, Boston, MA, USAGiulio Rasperini - 5University of Milan, Unit of Periodontology, Department of Surgical, Regenerative and Diagnostic Science, Foundation IRCCS Cà Granda Policlinico, Milan ItalySamuel E Lynch - 3Biomimetic Therapeutics, Inc., Franklin, TN, USAWilliam V Giannobile - 1University of Michigan School of Dentistry, Department of Periodontics and Oral Medicine and Michigan Center for Oral Health Research, 1011 North University Avenue, Ann Arbor, MI 48109 1078, USA william.giannobile@umich.edu
- Resource Type
- Journal article
- Publication Details
- Expert opinion on biological therapy, Vol.11(3), pp.375-385
- DOI
- 10.1517/14712598.2011.554814
- PMID
- 21288185
- PMCID
- PMC3056074
- NLM abbreviation
- Expert Opin Biol Ther
- ISSN
- 1471-2598
- eISSN
- 1744-7682
- Publisher
- Informa UK, Ltd
- Language
- English
- Date published
- 03/2011
- Academic Unit
- Periodontics
- Record Identifier
- 9984066090202771
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