Journal article
Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles
Blood, Vol.111(10), pp.5028-5036
Immunobiology
05/15/2008
DOI: 10.1182/blood-2007-06-097410
PMCID: PMC2384131
PMID: 18198347
Abstract
Although mounting evidence indicates that platelets participate in the modulation of both innate and adaptive immunity, the mechanisms by which platelets exert these effects have not been clearly defined. The study reported herein uses a previously documented adoptive transfer model to investigate the ability of platelet-derived membrane vesicles to communicate activation signals to the B-cell compartment. The findings demonstrate for the first time that platelet-derived membrane vesicles are sufficient to deliver CD154 to stimulate antigen-specific IgG production and modulate germinal center formation through cooperation with responses elicited by CD4
+
T cells. The data are consistent with the hypothesis that platelets modulate inflammation and adaptive immunity at sites distant from the location of activation and that platelet-derived membrane vesicles are sufficient to mediate the effect.
Details
- Title: Subtitle
- Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles
- Creators
- Daniel L Sprague - Department of Urology, University of Iowa, Iowa CityBennett D Elzey - Department of Comparative Pathobiology, Purdue University, West Lafayette, INScott A Crist - Department of Comparative Pathobiology, Purdue University, West Lafayette, INThomas J Waldschmidt - Department of Pathology, University of Iowa, Iowa CityRobert J Jensen - Department of Urology, University of Iowa, Iowa CityTimothy L Ratliff - Department of Urology, University of Iowa, Iowa City
- Resource Type
- Journal article
- Publication Details
- Blood, Vol.111(10), pp.5028-5036
- Publisher
- American Society of Hematology; Washington, DC
- Series
- Immunobiology
- DOI
- 10.1182/blood-2007-06-097410
- PMID
- 18198347
- PMCID
- PMC2384131
- ISSN
- 0006-4971
- eISSN
- 1528-0020
- Language
- English
- Date published
- 05/15/2008
- Academic Unit
- Pathology; Urology; Internal Medicine
- Record Identifier
- 9984046818002771
Metrics
9 Record Views