Journal article
Pluripotency transcription factors in the pathogenesis of colorectal cancer and implications for prognosis
Biomarkers in medicine, Vol.9(4), pp.349-361
03/01/2015
DOI: 10.2217/BMM.15.4
PMID: 25808439
Abstract
The cancer stem cell hypothesis argues that cancers depend on a specific type of cells, representing usually a small percentage of the total cancer cell population, termed cancer stem cells (or tumor-initiating cells) for their development and propagation. In colorectal cancer these cells express specific surface proteins such as CD133 and CD44 and can recapitulate the whole tumor. Besides expression of these surface markers, stem cells are associated with a network of pluripotency transcription factors, such as Oct4 and Sox2, which is present in them. Pluripotency factors are normally active in early development and characterize primitive cells, able to give rise to all different cell and tissue types of the three embryonic layers. In this review I will discuss the relationship of these factors with pathogenic lesions in colorectal cancer and their prognostic implications.
Details
- Title: Subtitle
- Pluripotency transcription factors in the pathogenesis of colorectal cancer and implications for prognosis
- Creators
- Ioannis A. Voutsadakis - Sault Area Hosp, Dept Internal Med, Div Med Oncol, Sault Ste Marie, ON P6B 0A8, Canada
- Resource Type
- Journal article
- Publication Details
- Biomarkers in medicine, Vol.9(4), pp.349-361
- Publisher
- Future Medicine Ltd
- DOI
- 10.2217/BMM.15.4
- PMID
- 25808439
- ISSN
- 1752-0363
- eISSN
- 1752-0371
- Number of pages
- 13
- Language
- English
- Date published
- 03/01/2015
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806500602771
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