Pneumococcal serotypes before and after introduction of conjugate vaccines, United States, 1999-2011(1.)

Sandra S Richter; Kristopher P Heilmann; Cassie L Dohrn; Fathollah Riahi; Daniel J Diekema; Gary V Doern

doi:10.3201/eid1907.121830

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Pneumococcal serotypes before and after introduction of conjugate vaccines, United States, 1999-2011(1.)

Journal article

Open access

Peer reviewed

Pneumococcal serotypes before and after introduction of conjugate vaccines, United States, 1999-2011(1.)

Sandra S Richter, Kristopher P Heilmann, Cassie L Dohrn, Fathollah Riahi, Daniel J Diekema and Gary V Doern

Emerging infectious diseases, Vol.19(7), pp.1074-1083

07/2013

DOI: 10.3201/eid1907.121830

PMID: 23763847

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Abstract

Serotyping data for pneumococci causing invasive and noninvasive disease in 2008-2009 and 2010-2011 from >43 US centers were compared with data from preconjugate vaccine (1999-2000) and postconjugate vaccine (2004-2005) periods. Prevalence of 7-valent pneumococcal conjugate vaccine serotypes decreased from 64% of invasive and 50% of noninvasive isolates in 1999-2000 to 3.8% and 4.2%, respectively, in 2010-2011. Increases in serotype 19A stopped after introduction of 13-valent pneumococcal vaccine (PCV13) in 2010. Prevalences of other predominant serotypes included in or related to PCV13 (3, 6C, 7F) also remained similar for 2008-2009 and 2010-2011. The only major serotype that increased from 2008-2009 to 2010-2011 was nonvaccine serotype 35B. These data show that introduction of the 7-valent vaccine has dramatically decreased prevalence of its serotypes and that addition of serotypes in PCV13 could provide coverage of 39% of isolates that continue to cause disease.

Streptococcus pneumoniae - classification

Age Distribution

Prevalence

United States

Humans

Middle Aged

Child, Preschool

Infant

Pneumococcal Vaccines

Streptococcus pneumoniae - immunology

Microbial Sensitivity Tests

Young Adult

Penicillin Resistance

Adult

Pneumococcal Infections - microbiology

Vaccines, Conjugate

Penicillins - pharmacology

Child

Serotyping

Streptococcus pneumoniae - drug effects

Pneumococcal Infections - epidemiology

Adolescent

Pneumococcal Infections - prevention & control

Aged

Anti-Bacterial Agents - pharmacology

Cluster Analysis

Details

Title: Subtitle: Pneumococcal serotypes before and after introduction of conjugate vaccines, United States, 1999-2011(1.)
Creators: Sandra S Richter - Cleveland Clinic, Cleveland, Ohio 44195, USA. richtes@ccf.org
Kristopher P Heilmann
Cassie L Dohrn
Fathollah Riahi
Daniel J Diekema
Gary V Doern
Resource Type: Journal article
Publication Details: Emerging infectious diseases, Vol.19(7), pp.1074-1083
DOI: 10.3201/eid1907.121830
PMID: 23763847
NLM abbreviation: Emerg Infect Dis
ISSN: 1080-6040
eISSN: 1080-6059
Publisher: United States
Language: English
Date published: 07/2013
Academic Unit: Infectious Diseases; Epidemiology; Pathology; Internal Medicine
Record Identifier: 9983986267102771

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