Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease

Brian D Hobbs; Marilyn G Foreman; Russell Bowler; Francine Jacobson; Barry J Make; Peter J Castaldi; Raúl San José Estépar; Edwin K Silverman; Craig P Hersh; COPDGene Investigators

doi:10.1513/AnnalsATS.201405-224OC

Back

Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease

Journal article

Open access

Peer reviewed

Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease

Brian D Hobbs, Marilyn G Foreman, Russell Bowler, Francine Jacobson, Barry J Make, Peter J Castaldi, Raúl San José Estépar, Edwin K Silverman, Craig P Hersh and COPDGene Investigators

Annals of the American Thoracic Society, Vol.11(9), pp.1387-1394

11/2014

DOI: 10.1513/AnnalsATS.201405-224OC

PMCID: PMC4298989

PMID: 25295410

Files and links (1)

url

https://doi.org/10.1513/AnnalsATS.201405-224OCView

Published (Version of record) Open Access

Abstract

The demographic, physiological, and computed tomography (CT) features associated with pneumothorax in smokers with and without chronic obstructive pulmonary disease (COPD) are not clearly defined. We evaluated the hypothesis that pneumothorax in smokers is associated with male sex, tall and thin stature, airflow obstruction, and increased total and subpleural emphysema. The study included smokers with and without COPD from the COPDGene Study, with quantitative chest CT analysis. Pleural-based emphysema was assessed on the basis of local histogram measures of emphysema. Pneumothorax history was defined by subject self-report. Pneumothorax was reported in 286 (3.2%) of 9,062 participants. In all participants, risk of prior pneumothorax was significantly higher in men (odds ratio [OR], 1.55; 95% confidence interval [CI], 1.08-2.22) and non-Hispanic white subjects (OR, 1.90; 95% CI, 1.34-2.69). Risk of prior pneumothorax was associated with increased percent CT emphysema in all participants and participants with COPD (OR, 1.04 for each 1% increase in emphysema; 95% CI, 1.03-1.06). Increased pleural-based emphysema was independently associated with risk of past pneumothorax in all participants (OR, 1.05 for each 1% increase; 95% CI, 1.01-1.10). In smokers with normal spirometry, risk of past pneumothorax was associated with non-Hispanic white race and lifetime smoking intensity (OR, 1.20 for every 10 pack-years; 95% CI, 1.09-1.33). Among smokers, pneumothorax is associated with male sex, non-Hispanic white race, and increased percentage of total and subpleural CT emphysema. Pneumothorax was not independently associated with height or lung function, even in participants with COPD. Clinical trial registered with www.clinicaltrials.gov (NCT00608764).

United States - epidemiology

Pneumothorax - epidemiology

Humans

Middle Aged

Risk Factors

European Continental Ancestry Group - statistics & numerical data

Male

Tomography, X-Ray Computed

Pulmonary Emphysema - diagnostic imaging

Pulmonary Disease, Chronic Obstructive - epidemiology

Pneumothorax - diagnostic imaging

Smoking - epidemiology

Sex Factors

Female

Details

Title: Subtitle: Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease
Creators: Brian D Hobbs - 1 Channing Division of Network Medicine and
Marilyn G Foreman
Russell Bowler
Francine Jacobson
Barry J Make
Peter J Castaldi
Raúl San José Estépar
Edwin K Silverman
Craig P Hersh
COPDGene Investigators
Contributors: Alejandro P Comellas Freymond (Contributor) - University of Iowa, Internal Medicine
Resource Type: Journal article
Publication Details: Annals of the American Thoracic Society, Vol.11(9), pp.1387-1394
DOI: 10.1513/AnnalsATS.201405-224OC
PMID: 25295410
PMCID: PMC4298989
NLM abbreviation: Ann Am Thorac Soc
ISSN: 2325-6621
eISSN: 2325-6621
Publisher: American Thoracic Society
Grant note: R01HL094635 / NHLBI NIH HHS T32 HL007427 / NHLBI NIH HHS R01 HL089856 / NHLBI NIH HHS R01 HL124233 / NHLBI NIH HHS P01HL105339 / NHLBI NIH HHS K01 HL092601 / NHLBI NIH HHS UL1 TR000005 / NCATS NIH HHS R01NR013377 / NINR NIH HHS R01HL089897 / NHLBI NIH HHS R01 NR013377 / NINR NIH HHS P01 HL105339 / NHLBI NIH HHS R01 HL089897 / NHLBI NIH HHS R01 HL094635 / NHLBI NIH HHS S21 MD000101 / NIMHD NIH HHS R01HL089856 / NHLBI NIH HHS
Language: English
Date published: 11/2014
Academic Unit: Pulmonary, Critical Care, and Occupational Medicine; ICTS; Internal Medicine
Record Identifier: 9984094703702771

Metrics

13 Record Views