Journal article
Polarity Sequence, Depression, and Chronicity in Bipolar I Disorder
The journal of nervous and mental disease, Vol.187(3), pp.181-187
03/1999
DOI: 10.1097/00005053-199903000-00008
PMID: 10086475
Abstract
Five independent studies show that polarity sequence is associated with prognosis in bipolar I disorder. Episodes in which major depression precedes mania (DMI) lead to higher morbidity than biphasic episodes which begin with mania (MDI). However, little is known about the prognostic significance of polarity sequence for long-term outcome. This study examined polarity sequence across multiple episodes among 165 bipolar I patients followed prospectively for up to 15 years as part of the NIMH Collaborative Study of Depression. Episodes beginning with major depression were significantly longer than those beginning with mania for the first three prospectively observed episodes when pooling all episode types-monophasic, biphasic, and polyphasic. Furthermore, affective polarity at onset for the first prospectively observed episode was associated with polarity at onset for the remaining three episodes. Patients whose first prospectively observed episode began with depression had higher overall morbidity during the entire follow-up period.
Details
- Title: Subtitle
- Polarity Sequence, Depression, and Chronicity in Bipolar I Disorder
- Creators
- CAROLYN TURVEYWILLIAM CORYELLSTEPHAN ARNDTDAVID SOLOMONANDREW LEONJEAN ENDICOTTTIMOTHY MUELLERMARTIN KELLERHAGOP AKISKAL
- Resource Type
- Journal article
- Publication Details
- The journal of nervous and mental disease, Vol.187(3), pp.181-187
- DOI
- 10.1097/00005053-199903000-00008
- PMID
- 10086475
- NLM abbreviation
- J Nerv Ment Dis
- ISSN
- 0022-3018
- eISSN
- 1539-736X
- Publisher
- Lippincott Williams & Wilkins, Inc
- Language
- English
- Date published
- 03/1999
- Academic Unit
- Psychiatry; Epidemiology; Biostatistics; Nursing; Injury Prevention Research Center
- Record Identifier
- 9984003911202771
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