Polo kinase and cytokinesis initiation in mammalian cells: harnessing the awesome power of chemical genetics

Catherine L Randall; Mark E Burkard; Prasad V Jallepalli

doi:10.4161/cc.6.14.4501

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Polo kinase and cytokinesis initiation in mammalian cells: harnessing the awesome power of chemical genetics

Journal article

Open access

Peer reviewed

Polo kinase and cytokinesis initiation in mammalian cells: harnessing the awesome power of chemical genetics

Catherine L Randall, Mark E Burkard and Prasad V Jallepalli

Cell cycle (Georgetown, Tex.), Vol.6(14), pp.1713-1717

07/15/2007

DOI: 10.4161/cc.6.14.4501

PMID: 17630508

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Abstract

The last decade has brought rapid advances in our knowledge of the human genome, as well as increasingly sophisticated methods to analyze how each of approximately 30,000 genes within it contribute to cellular, tissue, and organismal function. Here, we review this technological revolution in the context of Polo-like kinase 1 (Plk1), which has emerged as a central regulator of multiple processes fundamental to cell division. In particular, we highlight similarities and differences when Plk1 function is probed through various methods, including novel chemical inhibitors, and how our understanding of Plk1's role in mitosis and cell division has been enhanced as a consequence.

Animals

Antibodies - metabolism

Cell Cycle Proteins - antagonists & inhibitors

Cell Cycle Proteins - genetics

Cell Cycle Proteins - metabolism

Cytokinesis - physiology

Humans

Isoenzymes - antagonists & inhibitors

Isoenzymes - genetics

Isoenzymes - metabolism

Polo-Like Kinase 1

Protein Serine-Threonine Kinases - antagonists & inhibitors

Protein Serine-Threonine Kinases - genetics

Protein Serine-Threonine Kinases - metabolism

Proto-Oncogene Proteins - antagonists & inhibitors

Proto-Oncogene Proteins - genetics

Proto-Oncogene Proteins - metabolism

RNA Interference

Details

Title: Subtitle: Polo kinase and cytokinesis initiation in mammalian cells: harnessing the awesome power of chemical genetics
Creators: Catherine L Randall - Memorial Sloan Kettering Cancer Center
Mark E Burkard
Prasad V Jallepalli - Memorial Sloan Kettering Cancer Center
Resource Type: Journal article
Publication Details: Cell cycle (Georgetown, Tex.), Vol.6(14), pp.1713-1717
DOI: 10.4161/cc.6.14.4501
PMID: 17630508
ISSN: 1538-4101
eISSN: 1551-4005
Language: English
Date published: 07/15/2007
Academic Unit: Internal Medicine
Record Identifier: 9984701259702771

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