Journal article
Polychlorinated Biphenyl (PCB) carcinogenicity with special emphasis on airborne PCBs
Gefahrstoffe, Reinhaltung der Luft = Air quality control, Vol.71(1-2), pp.25-32
01/2011
PMCID: PMC3113507
PMID: 21686028
Abstract
Polychlorinated biphenyls (PCBs) are industrial chemicals used in various applications requiring chemical stabilityand have now become widely dispersed. Their characteristics of persistence, low water/higher lipid solubility, contribute to their ability to bioconcentrate and bioaccumulate. Traditionally PCBs have been regulated as food contaminants and the general population is primarily exposed by that route. PCBs in foodstuffs are generally higher chlorinated, resistant to metabolic breakdown, and elicit toxic changes that are thought to be predominantly receptor/parent PCB-driven. But for certain occupational exposures, and for those persons residing or working in contaminated buildings, and in large cities, an inhalation route of exposure may predominate. Airborne PCBs are, in contrast to foodborne PCBs, lower chlorinated, more volatile, and subject to metabolic attack. In this review, we have explored (geno-) toxic manifestations of PCBs typical of those found in air. Here metabolic conversion of the parent PCB to hydroxylated and other metabolic progeny appear to play a dominant role, especially in genotoxicity. We should be cognizant of the impact of exposures to airborne PCBs for those individuals who are occupationally exposed, for persons living near contaminated sites, for those who work or go to school in contaminated buildings, and especially cognizant of the young, the socio-economically disadvantaged and medically-underserved or nutritionally-deficient populations.
Details
- Title: Subtitle
- Polychlorinated Biphenyl (PCB) carcinogenicity with special emphasis on airborne PCBs
- Creators
- Larry W Robertson - Interdisciplinary Graduate Program in Human Toxicology, University of IowaGabriele Ludewig
- Resource Type
- Journal article
- Publication Details
- Gefahrstoffe, Reinhaltung der Luft = Air quality control, Vol.71(1-2), pp.25-32
- Publisher
- Germany
- PMID
- 21686028
- PMCID
- PMC3113507
- ISSN
- 0949-8036
- eISSN
- 1436-4891
- Grant note
- P30 ES005605 / NIEHS NIH HHS P42 ES013661 / NIEHS NIH HHS P42 ES013661-01A1 / NIEHS NIH HHS P42 ES013661-05 / NIEHS NIH HHS P42 ES013661-02 / NIEHS NIH HHS P42 ES013661-03S1 / NIEHS NIH HHS P42 ES013661-02S1 / NIEHS NIH HHS P42 ES013661-06 / NIEHS NIH HHS P42 ES013661-03 / NIEHS NIH HHS P42 ES013661-02S2 / NIEHS NIH HHS P42 ES013661-05S1 / NIEHS NIH HHS P30 ES005605-20 / NIEHS NIH HHS P42 ES013661-04 / NIEHS NIH HHS
- Language
- English
- Date published
- 01/2011
- Academic Unit
- Occupational and Environmental Health; Iowa Superfund Research Program
- Record Identifier
- 9983997467102771
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