Journal article
Polycomb group repression is blocked by the Drosophila suppressor of Hairy-wing [su(Hw)] insulator
Genetics (Austin), Vol.148(1), pp.331-339
01/1998
PMCID: PMC1459791
PMID: 9475743
Abstract
The suppressor of Hairy-wing [SU(HW)] binding region disrupts communication between a large number of enhancers and promoters and protects transgenes from chromosomal position effects. These properties classify the SU(HW) binding region as an insulator. While enhancers are blocked in a general manner, protection from repressors appears to be more variable. In these studies, we address whether repression resulting from the Polycomb group genes can be blocked by the SU(HW) binding region. The effects of this binding region on repression established by an Ultrabithorax Polycomb group Response Element were examined. A transposon carrying two reporter genes, the yellow and white genes, was used so that repression and insulation could be assayed simultaneously. We demonstrate that the SU(HW) binding region is effective at preventing Polycomb group repression. These studies suggest that one role of the su(Hw) protein may be to restrict the range of action of repressors, such as the Polycomb group proteins, throughout the euchromatic regions of the genome.
Details
- Title: Subtitle
- Polycomb group repression is blocked by the Drosophila suppressor of Hairy-wing [su(Hw)] insulator
- Creators
- D R Mallin - Department of Biochemistry, The University of Iowa, Iowa City 52242, USAJ S Myung - Department of Biochemistry, The University of Iowa, Iowa City 52242, USAJ Scott Patton - Department of Biochemistry, The University of Iowa, Iowa City 52242, USAPamela K Geyer - Department of Biochemistry, The University of Iowa, Iowa City 52242, USA
- Resource Type
- Journal article
- Publication Details
- Genetics (Austin), Vol.148(1), pp.331-339
- PMID
- 9475743
- PMCID
- PMC1459791
- ISSN
- 0016-6731
- eISSN
- 1943-2631
- Language
- English
- Date published
- 01/1998
- Academic Unit
- Obstetrics and Gynecology; Biochemistry and Molecular Biology
- Record Identifier
- 9984024537302771
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