Journal article
Polycystic kidney disease and cancer after renal transplantation
Journal of the American Society of Nephrology, Vol.25(10), pp.2335-2341
10/2014
DOI: 10.1681/ASN.2013101122
PMCID: PMC4178444
PMID: 24854270
Abstract
Autosomal dominant polycystic kidney disease (ADPKD), the most common form of polycystic kidney disease (PKD), is a disorder with characteristics of neoplasia. However, it is not known whether renal transplant recipients with PKD have an increased risk of cancer. Data from the Scientific Registry of Transplant Recipients, which contains information on all solid organ transplant recipients in the United States, were linked to 15 population-based cancer registries in the United States. For PKD recipients, we compared overall cancer risk with that in the general population. We also compared cancer incidence in PKD versus non-PKD renal transplant recipients using Poisson regression, and we determined incidence rate ratios (IRRs) adjusted for age, sex, race/ethnicity, dialysis duration, and time since transplantation. The study included 10,166 kidney recipients with PKD and 107,339 without PKD. Cancer incidence in PKD recipients was 1233.6 per 100,000 person-years, 48% higher than expected in the general population (standardized incidence ratio, 1.48; 95% confidence interval [95% CI], 1.37 to 1.60), whereas cancer incidence in non-PKD recipients was 1119.1 per 100,000 person-years. The unadjusted incidence was higher in PKD than in non-PKD recipients (IRR, 1.10; 95% CI, 1.01 to 1.20). However, PKD recipients were older (median age at transplantation, 51 years versus 45 years for non-PKD recipients), and after multivariable adjustment, cancer incidence was lower in PKD recipients than in others (IRR, 0.84; 95% CI, 0.77 to 0.91). The reason for the lower cancer risk in PKD recipients is not known but may relate to biologic characteristics of ADPKD or to cancer risk behaviors associated with ADPKD.
Details
- Title: Subtitle
- Polycystic kidney disease and cancer after renal transplantation
- Creators
- James B Wetmore - Department of Medicine, Division of Nephrology, The Kidney Institute, james.wetmore@hcmed.orgJames P Calvet - The Kidney Institute, Department of Biochemistry and Molecular Biology, and Department of Cancer Biology, University of Kansas School of Medicine, Kansas City, KansasAlan S L Yu - Department of Medicine, Division of Nephrology, The Kidney InstituteCharles F Lynch - Department of Epidemiology, University of Iowa, Iowa City, IowaConnie J WangBertram L Kasiske - Department of Medicine, Division of Nephrology, Hennepin County Medical Center, Minneapolis, Minnesota; andEric A Engels - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland
- Resource Type
- Journal article
- Publication Details
- Journal of the American Society of Nephrology, Vol.25(10), pp.2335-2341
- Publisher
- United States
- DOI
- 10.1681/ASN.2013101122
- PMID
- 24854270
- PMCID
- PMC4178444
- ISSN
- 1046-6673
- eISSN
- 1533-3450
- Grant note
- N01PC35142 / NCI NIH HHS HHSN261201000024C / NCI NIH HHS U58 DP000807 / NCCDPHP CDC HHS U58 DP000824 / NCCDPHP CDC HHS HHSN261201000036C / NCI NIH HHS U58 DP000848 / NCCDPHP CDC HHS HHSN261201000034C / NCI NIH HHS U58 DP003875 / NCCDPHP CDC HHS N01PC35139 / NCI NIH HHS P30 CA086862 / NCI NIH HHS N01PC35137 / NCI NIH HHS U58 DP000812 / NCCDPHP CDC HHS HHSN261201000037C / NCI NIH HHS Intramural NIH HHS U58 DP000832 / NCCDPHP CDC HHS HHSN261201000035C / NCI NIH HHS U58 DP003879 / NCCDPHP CDC HHS N01PC35143 / NCI NIH HHS HHSN261201000027C / NCI NIH HHS HHSN261201000026C / NCI NIH HHS U58 DP000805 / NCCDPHP CDC HHS HHSN261201000035I / NCI NIH HHS
- Language
- English
- Date published
- 10/2014
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995153302771
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