Poly(ether-anhydride) dry powder aerosols for sustained drug delivery in the lungs

Jennifer Fiegel; Jie Fu; Justin Hanes

doi:10.1016/j.jconrel.2004.02.018

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Poly(ether-anhydride) dry powder aerosols for sustained drug delivery in the lungs

Journal article

Peer reviewed

Poly(ether-anhydride) dry powder aerosols for sustained drug delivery in the lungs

Jennifer Fiegel, Jie Fu and Justin Hanes

Journal of controlled release, Vol.96(3), pp.411-423

05/18/2004

DOI: 10.1016/j.jconrel.2004.02.018

PMID: 15120898

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Abstract

A new family of biodegradable ether-anhydride polymers was used to develop microparticles capable of controlled drug release and inhalation as a dry powder. The polymers are composed of various ratios of sebacic acid (SA) (to render the polymer insoluble in water) and poly(ethylene glycol) (PEG) (to reduce particle clearance by macrophages and improve aerosolization). Particle aerodynamic diameter was controlled within the respirable range by producing geometrically large, but low density particles as a first step toward reducing particle adhesion forces that limit efficient aerosolization of dry powders. Particles made from a variety of polymer compositions possessed high emitted doses (>80%) from a Spinhaler dry powder inhaler (DPI). Control over particle surface and bulk properties (surface roughness, surface charge, density and water retention) was achieved by varying the percentage of PEG in the polymer backbone. The addition of 10% PEG into the polymer backbone significantly enhanced deposition in the lower stages of an in vitro lung model following aerosolization from the DPI (fine particle fractions [FPF] reached 30%). Efficient aerosolization from an obsolete DPI combined with the ability to evade phagocytic clearance and provide controlled release of various drug molecules make these particles promising for prolonged drug delivery in the lung.

Aerosols

Anesthesia, Inhalation

Anhydrides - chemistry

Decanoic Acids - chemistry

Delayed-Action Preparations

Dicarboxylic Acids - chemistry

Excipients

Image Processing, Computer-Assisted

Lung - metabolism

Microscopy, Electron, Scanning

Microspheres

Molecular Weight

Particle Size

Polyethylene Glycols - chemistry

Polymers

Powders

Surface Properties

Details

Title: Subtitle: Poly(ether-anhydride) dry powder aerosols for sustained drug delivery in the lungs
Creators: Jennifer Fiegel - Johns Hopkins University
Jie Fu - Johns Hopkins University
Justin Hanes - Johns Hopkins University
Resource Type: Journal article
Publication Details: Journal of controlled release, Vol.96(3), pp.411-423
DOI: 10.1016/j.jconrel.2004.02.018
PMID: 15120898
ISSN: 0168-3659
eISSN: 1873-4995
Language: English
Date published: 05/18/2004
Academic Unit: Pharmaceutical Sciences and Experimental Therapeutics; Chemical and Biochemical Engineering
Record Identifier: 9984197250402771

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