Polygenic Risk for Externalizing Disorders: Gene-by-Development and Gene-by-Environment Effects in Adolescents and Young Adults

Jessica E. Salvatore; Fazil Aliev; Kathleen Bucholz; Arpana Agrawal; Victor Hesselbrock; Michie Hesselbrock; Lance Bauer; Samuel Kuperman; Marc A. Schuckit; John R. Kramer; Howard J. Edenberg; Tatiana M. Foroud; Danielle M. Dick

doi:10.1177/2167702614534211

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Polygenic Risk for Externalizing Disorders: Gene-by-Development and Gene-by-Environment Effects in Adolescents and Young Adults

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Polygenic Risk for Externalizing Disorders: Gene-by-Development and Gene-by-Environment Effects in Adolescents and Young Adults

Jessica E. Salvatore, Fazil Aliev, Kathleen Bucholz, Arpana Agrawal, Victor Hesselbrock, Michie Hesselbrock, Lance Bauer, Samuel Kuperman, Marc A. Schuckit, John R. Kramer, …

Clinical psychological science, Vol.3(2), pp.189-201

03/01/2015

DOI: 10.1177/2167702614534211

PMCID: PMC4371857

PMID: 25821660

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https://soar.suny.edu/bitstream/20.500.12648/8140/1/nihms586638.pdfView

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Abstract

In this project, we aimed to bring large-scale gene-identification findings into a developmental psychopathology framework. Using a family-based sample, we tested whether polygenic scores for externalizing disorders-based on single nucleotide polymorphism weights derived from genome-wide association study results in adults (n = 1,249)predicted externalizing disorders, subclinical externalizing behavior, and impulsivity-related traits among adolescents (n = 248) and young adults (n = 207) and whether parenting and peer factors in adolescence moderated polygenic risk to predict externalizing disorders. Polygenic scores predicted externalizing disorders in adolescents and young adults, even after we controlled for parental externalizing-disorder history. Polygenic scores also predicted subclinical externalizing behavior and impulsivity traits in the adolescents and young adults. Adolescent parental monitoring and peer substance use moderated polygenic scores to predict externalizing disorders. This illustrates how state-of-the-science genetics can be integrated with psychological science to identify how genetic risk contributes to the development of psychopathology.

Life Sciences & Biomedicine

Psychiatry

Psychology

Psychology, Clinical

Science & Technology

Social Sciences

Details

Title: Subtitle: Polygenic Risk for Externalizing Disorders: Gene-by-Development and Gene-by-Environment Effects in Adolescents and Young Adults
Creators: Jessica E. Salvatore - Virginia Commonwealth University
Fazil Aliev - Virginia Commonwealth University
Kathleen Bucholz - 2Department of Psychiatry, Washington University
Arpana Agrawal - 2Department of Psychiatry, Washington University
Victor Hesselbrock - University of Connecticut
Michie Hesselbrock - University of Connecticut
Lance Bauer - University of Connecticut
Samuel Kuperman - University of Iowa
Marc A. Schuckit - University of California San Diego
John R. Kramer - University of Iowa
Howard J. Edenberg - Indiana University
Tatiana M. Foroud - Indiana University
Danielle M. Dick - Virginia Commonwealth University
Resource Type: Journal article
Publication Details: Clinical psychological science, Vol.3(2), pp.189-201
DOI: 10.1177/2167702614534211
PMID: 25821660
PMCID: PMC4371857
NLM abbreviation: Clin Psychol Sci
ISSN: 2167-7026
eISSN: 2167-7034
Publisher: Sage
Number of pages: 13
Grant note: T32MH020030 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) U10AA008401 / National Institutes of Health (NIH) from the National Institute on Alcohol Abuse and Alcoholism U10AA008401 / National Institutes of Health (NIH) Grant from National Institute on Drug Abuse UL1TR000448 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) K02DA032573 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission NIH Roadmap for Medical Research; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA UL1RR024992 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) UL1RR024992 / Institute of Clinical and Translational Sciences/Clinical and Translational Science Award from the National Center for Research Resources (NCRR), a component of the NIH P30 CA91842 / NCI Cancer Center Support Grant; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) U10AA008401 / NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA)
Language: English
Date published: 03/01/2015
Academic Unit: Psychiatry
Record Identifier: 9984293753502771

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