Journal article
Polymer Coated Echogenic Lipid Nanoparticles with Dual Release Triggers
Biomacromolecules, Vol.14(3), pp.841-853
02/20/2013
DOI: 10.1021/bm301894z
PMCID: PMC3595326
PMID: 23394107
Abstract
Although lipid nanoparticles are promising drug delivery vehicles, passive release of encapsulated contents at the target site is often slow. Herein, we report contents release from targeted, polymer coated, echogenic lipid nanoparticles in the cell cytoplasm by redox trigger and simultaneously enhanced by diagnostic frequency ultrasound. The lipid nanoparticles were polymerized on the external leaflet using a disulfide cross-linker. In the presence of cytosolic concentrations of glutathione, the lipid nanoparticles released 76% of encapsulated contents. Plasma concentrations of glutathione failed to release the encapsulated contents. Application of 3 MHz ultrasound for 2 minutes simultaneously with the reducing agent enhanced the release to 96%. Folic acid conjugated, doxorubicin loaded nanoparticles showed enhanced uptake and higher cytotoxicity in cancer cells overexpressing the folate receptor (compared to the control). With further developments, these lipid nanoparticles have the potential to be used as multimodal nanocarriers for simultaneous targeted drug delivery and ultrasound imaging.
Details
- Title: Subtitle
- Polymer Coated Echogenic Lipid Nanoparticles with Dual Release Triggers
- Creators
- Rahul Nahire - North Dakota State UniversityManas K. Haldar - Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota 58108 Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108 Department of Civil Engineering, North Dakota State University, Fargo, North Dakota 58108 Department of Mechanical Engineering, University of Delaware, Newark, Delaware 19716 Department of Mechanical and Aerospace Engineering, George Washington University, Washington, District of Columbia 20052 Department of Health, Nutrition and Exercise Sciences, North Dakota State University, Fargo, North Dakota 58108Shirshendu Paul - University of DelawareAnaas Mergoum - Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota 58108 Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108 Department of Civil Engineering, North Dakota State University, Fargo, North Dakota 58108 Department of Mechanical Engineering, University of Delaware, Newark, Delaware 19716 Department of Mechanical and Aerospace Engineering, George Washington University, Washington, District of Columbia 20052 Department of Health, Nutrition and Exercise Sciences, North Dakota State University, Fargo, North Dakota 58108Avinash H. Ambre - Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota 58108 Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108 Department of Civil Engineering, North Dakota State University, Fargo, North Dakota 58108 Department of Mechanical Engineering, University of Delaware, Newark, Delaware 19716 Department of Mechanical and Aerospace Engineering, George Washington University, Washington, District of Columbia 20052 Department of Health, Nutrition and Exercise Sciences, North Dakota State University, Fargo, North Dakota 58108Kalpana S. Katti - Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota 58108 Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108 Department of Civil Engineering, North Dakota State University, Fargo, North Dakota 58108 Department of Mechanical Engineering, University of Delaware, Newark, Delaware 19716 Department of Mechanical and Aerospace Engineering, George Washington University, Washington, District of Columbia 20052 Department of Health, Nutrition and Exercise Sciences, North Dakota State University, Fargo, North Dakota 58108Kara N. Gange - North Dakota State UniversityD. K. Srivastava - North Dakota State UniversityKausik Sarkar - George Washington UniversitySanku Mallik - Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota 58108 Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108 Department of Civil Engineering, North Dakota State University, Fargo, North Dakota 58108 Department of Mechanical Engineering, University of Delaware, Newark, Delaware 19716 Department of Mechanical and Aerospace Engineering, George Washington University, Washington, District of Columbia 20052 Department of Health, Nutrition and Exercise Sciences, North Dakota State University, Fargo, North Dakota 58108
- Resource Type
- Journal article
- Publication Details
- Biomacromolecules, Vol.14(3), pp.841-853
- DOI
- 10.1021/bm301894z
- PMID
- 23394107
- PMCID
- PMC3595326
- NLM abbreviation
- Biomacromolecules
- ISSN
- 1525-7797
- eISSN
- 1526-4602
- Grant note
- R01 CA132034 || CA / National Cancer Institute : NCI
- Language
- English
- Date published
- 02/20/2013
- Academic Unit
- Orthopedics and Rehabilitation
- Record Identifier
- 9984304703702771
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