Polymicrobial acute respiratory infections in a hospital-based pediatric population

Margaret L Chorazy; Mark G Lebeck; Troy A McCarthy; Sandra S Richter; James C Torner; Gregory C Gray

doi:10.1097/INF.0b013e31828683ce

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Polymicrobial acute respiratory infections in a hospital-based pediatric population

Journal article

Open access

Peer reviewed

Polymicrobial acute respiratory infections in a hospital-based pediatric population

Margaret L Chorazy, Mark G Lebeck, Troy A McCarthy, Sandra S Richter, James C Torner and Gregory C Gray

The Pediatric infectious disease journal, Vol.32(5), pp.460-466

05/2013

DOI: 10.1097/INF.0b013e31828683ce

PMCID: PMC3701747

PMID: 23348811

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Abstract

The clinical impact of polymicrobial respiratory infections remains uncertain. Previous reports are contradictory regarding an association with severe disease. Three hundred forty-six specimens from children with acute respiratory illness identified at the University of Iowa Hospitals and Clinics Clinical Microbiology Laboratory were evaluated by direct immunofluorescent assay and/or viral culture by Clinical Microbiology Laboratory and later by molecular study for the presence of influenza, parainfluenza, respiratory syncytial virus, adenovirus, human metapneumovirus, rhinovirus and human bocavirus. Demographic and clinical data were abstracted from medical records. Multiple viruses were detected in 46 (21.7%) of 212 virus-positive specimens with the most frequent virus-virus combinations being HRV-respiratory syncytial virus (n = 12), HRV-human bocavirus (n = 6) and HRV-parainfluenza virus 3 (n = 4). Risk factors for coinfection included male gender (OR [odds ratio]: 1.70, 95% confidence interval [CI]: 0.83-3.46), 6 months to 1 year age (OR: 2.15, 95% CI: 0.75-6.19) and history of immunosuppression (OR: 2.05, 95% CI: 0.99-4.23). Children with viral coinfections were less likely than children with single virus infections to be admitted to an intensive care unit (OR: 0.32, 95% CI: 0.08-1.27); however, this may be explained by undetected viral-bacterial coinfections. HRV, respiratory syncytial virus, human bocavirus, and polymicrobial infections were prevalent in this study. Although the cross-sectional design could not easily examine polymicrobial infection and disease severity, prospective, population-based research regarding the clinical impact of such infections is warranted.

Acute Disease

Cross-Sectional Studies

Humans

Risk Factors

Child, Preschool

Hospitals, Pediatric

Infant

Male

Virus Diseases - virology

Virus Diseases - microbiology

Coinfection - virology

Respiratory Tract Infections - microbiology

Bacterial Infections - virology

Coinfection - microbiology

Female

Retrospective Studies

Respiratory Tract Infections - virology

Child

Bacterial Infections - microbiology

Details

Title: Subtitle: Polymicrobial acute respiratory infections in a hospital-based pediatric population
Creators: Margaret L Chorazy - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA. margaret-chorazy@uiowa.edu
Mark G Lebeck
Troy A McCarthy
Sandra S Richter
James C Torner
Gregory C Gray
Resource Type: Journal article
Publication Details: The Pediatric infectious disease journal, Vol.32(5), pp.460-466
DOI: 10.1097/INF.0b013e31828683ce
PMID: 23348811
PMCID: PMC3701747
NLM abbreviation: Pediatr Infect Dis J
ISSN: 1532-0987
eISSN: 1532-0987
Publisher: United States
Grant note: R01 AI053034 / NIAID NIH HHS R01 AI068803 / NIAID NIH HHS
Language: English
Date published: 05/2013
Academic Unit: Public Health Administration; Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995025102771

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