Journal article
Polymorphism of FCGR3A gene in chronic beryllium disease
Genes and immunity, Vol.20(6), pp.493-499
07/2019
DOI: 10.1038/s41435-018-0046-8
PMCID: PMC6431584
PMID: 30245507
Abstract
Previously we showed that alveolar macrophages (AMs) from patients with chronic beryllium disease (CBD) and beryllium sensitization (BeS) demonstrated significantly greater cell surface CD16 (encoded by the FCGR3A gene) than controls. We hypothesized that these differences were related to polymorphisms in the FCGR3A gene. This study was to determine the association between FCGR3A polymorphisms in CBD, BeS versus controls as well as clinical data, providing potential information about disease pathogenesis, risk, and activity. A total of 189 CBD/154 BeS/150 controls (92 Be-exposed non-diseased and 58 healthy controls) were included in this study. Sequence-specific primers polymerase chain reaction (PCR-SSP) was used to determine FCGR3A 158V/F polymorphisms. We found significantly higher frequencies of the 158V allele (OR: 1.60 (CI: 1.17-2.19), p = 0.004) and 158VV homozygotes (OR: 2.97 (CI: 1.48-5.97) p = 0.007) in CBD versus controls. No differences were found in the frequencies of FCGR3A alleles or genotypes between BeS versus controls and CBD versus BeS. Average changes in exercise testing maximum workload (Wlm), maximum oxygen consumption (VO
m), and diffusion capacity of carbon monoxide (DLCO) demonstrated greater decline over time in those CBD cases with the 158VV gene, modeled between 10 and 40 years from first beryllium exposure. The FCGR3A V158F polymorphism is associated with CBD compared to BeS and controls and may impact lung function in CBD.
Details
- Title: Subtitle
- Polymorphism of FCGR3A gene in chronic beryllium disease
- Creators
- Bing Liu - National Jewish HealthLisa A Maier - Colorado School of Public HealthNabeel Hamzeh - National Jewish HealthKristyn MacPhail - National Jewish HealthMargaret M Mroz - National Jewish HealthHongbo Liu - National Jewish HealthLi Li - National Jewish Health
- Resource Type
- Journal article
- Publication Details
- Genes and immunity, Vol.20(6), pp.493-499
- DOI
- 10.1038/s41435-018-0046-8
- PMID
- 30245507
- PMCID
- PMC6431584
- ISSN
- 1466-4879
- eISSN
- 1476-5470
- Grant note
- R01 ES025722 / NIEHS NIH HHS P01 ES011810 / NIEHS NIH HHS K01 ES020857 / NIEHS NIH HHS R01 ES025722 / National Institute of Environmental Health Sciences P01 ES011810 / National Institute of Environmental Health Sciences R01 ES023826 / National Institute of Environmental Health Sciences UL1 TR001082 / National Center for Advancing Translational Sciences R01 ES023826 / NIEHS NIH HHS K01 ES020857 / National Institute of Environmental Health Sciences
- Language
- English
- Date published
- 07/2019
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984359568702771
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