Polymorphism of HLA-DQB1 alleles in Chinese Han patients with Vogt-Koyanagi-Harada syndrome

Han-Yi Min; Ying Liu; Ni-Fang Niu; Mei-Fen Zhang; Xi-Lin Zhu; Jia-Liang Zhao

doi:10.3760/j.issn:0412-4081.2007.04.014

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Journal article

Polymorphism of HLA-DQB1 alleles in Chinese Han patients with Vogt-Koyanagi-Harada syndrome

Han-Yi Min, Ying Liu, Ni-Fang Niu, Mei-Fen Zhang, Xi-Lin Zhu and Jia-Liang Zhao

Chung-hua yen k'o tsa chih, Vol.43(4), pp.355-360

04/2007

DOI: 10.3760/j.issn:0412-4081.2007.04.014

PMID: 17605936

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Abstract

To investigate the frequency of HLA-DQB1 alleles in Chinese Han patients with Vogt-Koyanagi-Harada syndrome (VKH) and to analyze the relationships among the alleles and clinical manifestations. Eighty-eight Chinese Han patients with VKH and 88 non-VKH normal controls were admitted. DNA was extracted from white blood cells of the subjects by phenol-chloroform method. Thirteen alleles were typed by polymerase chain reaction-sequence specific primer (PCR-SSP). Relationships among alleles and clinical features were analyzed. Twelve of thirteen already known HLA-DQB1 alleles were typed by PCR-SSP in patients with VKH. The most frequent allele in patients with VKH was HLA-DQB1*0401 (31.8%) and this was significantly higher than that of normal controls (31.8% vs. 4.6%, chi(2) = 44.00, P = 0.000, OR = 9.8, 95% CI 4.51 - 21.31). So was for HLA-DQB1*0303 (6.8% vs. 0.6%, chi(2) = 9.67, P = 0.002, OR = 12.81, 95% CI 1.65 - 99.58). On the contrary, the frequency of HLA-DQB1*0601 (1.7% vs. 9.7%, chi(2) = 10.39, P = 0.001,

Adolescent

Adult

Aged

Alleles

Asian Continental Ancestry Group - genetics

Case-Control Studies

Female

Gene Frequency

HLA-DQ Antigens - genetics

HLA-DQ beta-Chains

Humans

Male

Middle Aged

Polymorphism, Genetic

Uveomeningoencephalitic Syndrome - ethnology

Uveomeningoencephalitic Syndrome - genetics

Uveomeningoencephalitic Syndrome - immunology

Young Adult

Details

Title: Subtitle: Polymorphism of HLA-DQB1 alleles in Chinese Han patients with Vogt-Koyanagi-Harada syndrome
Creators: Han-Yi Min - Peking Union Medical College Hospital
Ying Liu
Ni-Fang Niu
Mei-Fen Zhang
Xi-Lin Zhu
Jia-Liang Zhao
Resource Type: Journal article
Publication Details: Chung-hua yen k'o tsa chih, Vol.43(4), pp.355-360
DOI: 10.3760/j.issn:0412-4081.2007.04.014
PMID: 17605936
NLM abbreviation: Zhonghua Yan Ke Za Zhi
ISSN: 0412-4081
Language: Chinese
Date published: 04/2007
Academic Unit: Stead Family Department of Pediatrics; Medical Genetics and Genomics
Record Identifier: 9984701649902771

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