Journal article
Polymorphisms in the transforming growth factor beta 3 gene and their associations with feed efficiency in chickens
Poultry science, Vol.92(7), pp.1745-1749
07/01/2013
DOI: 10.3382/ps.2013-03018
PMID: 23776260
Abstract
Growth and feeding traits such as BW, BW gain (BWG), feed intake (FI), and feed conversion ratio (FCR) are of economic importance in poultry production. In this study, 8 SNP of the transforming growth factor beta 3 (TGF-beta 3) gene, which are located in the proximity of quantitative trait loci affecting BW and FCR, were selected to be genotyped by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in 2 yellow meat-type chicken populations with 724 birds in total. Body weights at 49 (BW49) and 70 (BW70) d of age and FI in the interval were recorded, and respective BWG and FCR were calculated for each bird. Two SNP with a very low minor allele frequency (<1%) were discarded from further analysis. The results showed that both rs13586818 and rs14535174 had significant effects (P < 0.05) on BWG and FCR, and that rs14535177 was significantly (P < 0.05) associated with BW49, BW70, and FI. Furthermore, birds with the GA genotype of rs13586818 showed strongly higher FCR and lower BWG (P < 0.05) compared with AA individuals. The TT birds had significantly larger BWG (P < 0.05) than GT birds in rs14535174, whereas FCR was the opposite. Individuals with the GC genotype of rs14535177 had significantly higher BW49, BW70, FCR, and FI (P < 0.05) than those with the GG genotype. Additionally, haplotypes based on 3 SNP of rs13586818, rs14535174, and rs14535177 were significantly associated with FCR (P < 0.05). The SNP and analyzed haplotypes identified in this study might be used as potential genetic markers in meat-type chicken breeding.
Details
- Title: Subtitle
- Polymorphisms in the transforming growth factor beta 3 gene and their associations with feed efficiency in chickens
- Creators
- Sihua Jin - China Agricultural UniversitySirui Chen - China Agricultural UniversityHuifeng Li - Shanxi Agricultural UniversityYue Lu - China Agricultural UniversityDexiang Zhang - Wen's Food Group (China)Congliang Ji - Wen's Food Group (China)Guiyun Xu - China Agricultural UniversityNing Yang - China Agricultural University
- Resource Type
- Journal article
- Publication Details
- Poultry science, Vol.92(7), pp.1745-1749
- DOI
- 10.3382/ps.2013-03018
- PMID
- 23776260
- NLM abbreviation
- Poult Sci
- ISSN
- 0032-5791
- eISSN
- 1525-3171
- Publisher
- Oxford Univ Press
- Number of pages
- 5
- Grant note
- 2012QJ096 / Chinese Universities Scientific Fund IRT0945; IRT1191 / Programs for Changjiang Scholars and Innovative Research in University of China 31201794; 31172203 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC)
- Language
- English
- Date published
- 07/01/2013
- Academic Unit
- Biochemistry and Molecular Biology
- Record Identifier
- 9985150302402771
Metrics
1 Record Views