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Polytolypin, a New Antifungal Triterpenoid from the Coprophilous Fungus Polytolypa hystricis
Journal article   Peer reviewed

Polytolypin, a New Antifungal Triterpenoid from the Coprophilous Fungus Polytolypa hystricis

William R Gamble, James B Gloer, James A Scott and David Malloch
Journal of natural products (Washington, D.C.), Vol.58(12), pp.1983-1986
12/01/1995
DOI: 10.1021/np50126a034
PMID: 8691217

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Abstract

Polytolypin [1], a new pentacyclic triterpenoid exhibiting antifungal and antibiotic activity, has been isolated from cultures of Polytolypa hystricis (JS189), a fungal colonist of porcupine dung. Two known compounds [2 and 3] were also isolated. Polytolypin was obtained by chromatographic fractionation of the EτOAc extract of P. hystricis liquid cultures, and the structure was assigned on the basis of 2D nmr and hrms data. © 1995, American Chemical Society. All rights reserved.

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