Journal article
Polyunsaturated fatty acid composition and childhood adversity: Independent correlates of depressive symptom persistence
Psychiatry research, Vol.256, pp.305-311
10/2017
DOI: 10.1016/j.psychres.2017.06.036
PMCID: PMC6193447
PMID: 28666200
Abstract
Childhood experiences, personality, and polyunsaturated essential fatty acid (PUFA) composition have all been shown to affect the likelihood of depressive symptoms. Few studies have addressed relationships between these factors in their influence on the occurrence or course of depressive symptoms. The following analysis was designed to do so. Subjects, 15–20 years old, had either begun antidepressant treatment within the preceding month (n = 88), or had never taken psychiatric medications (n = 92). Baseline assessments included a structured diagnostic interview, the self-completed Multiphasic Personality Questionnaire, and a determination of plasma PUFA phospholipid composition. Depressive symptom levels were assessed at baseline and again at 4, 8 and 12 months. Omega-3 composition and general childhood trauma scores were unrelated to each other but both correlated, in predicted directions, with negative emotionality. Low omega-3 composition and history of childhood trauma were associated with persistence of depressive symptoms during follow-up, largely through their effects on negative emotionality. Negative emotionality appears to comprise a final common pathway to depressive disorder through which the diverse risk factors of childhood adversity and low omega-3 composition are expressed.
Details
- Title: Subtitle
- Polyunsaturated fatty acid composition and childhood adversity: Independent correlates of depressive symptom persistence
- Creators
- William H Coryell - Department of Psychiatry, University of Iowa Carver College of Medicine, 500 N Road, Suite 2-205 MEB, Iowa City, IA 52242-1900, USADouglas R Langbehn - Department of Psychiatry, University of Iowa Carver College of Medicine, 500 N Road, Suite 1-290 MEB, Iowa City, IA 52242-1900, USAAndrew W Norris - Department of Pediatrics, University of Iowa Carver College of Medicine, 285 N Road, 1270B CBRB, Iowa City, IA 52242-1900, USAJian-Rong Yao - Department of Pediatrics, University of Iowa Carver College of Medicine, 285 N Road, 1270 CBRB, Iowa City, IA 52242-1900, USALilian N Dindo - Department of Psychiatry, Baylor College of Medicine, Houston, TX, USAChadi A Calarge - Department of Psychiatry and Pediatrics, Baylor College of Medicine, Houston, TX, USA
- Resource Type
- Journal article
- Publication Details
- Psychiatry research, Vol.256, pp.305-311
- DOI
- 10.1016/j.psychres.2017.06.036
- PMID
- 28666200
- PMCID
- PMC6193447
- NLM abbreviation
- Psychiatry Res
- ISSN
- 0165-1781
- eISSN
- 1872-7123
- Publisher
- Elsevier B.V
- Grant note
- DOI: 10.13039/100000025, name: National Institute of Mental Health, award: R01MH090072; DOI: 10.13039/100000097, name: National Center for Research Resources, award: 2UL1TR000442-06; DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases, award: R01DK097820
- Language
- English
- Date published
- 10/2017
- Academic Unit
- Endocrinology and Diabetes; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Biochemistry and Molecular Biology; Urology
- Record Identifier
- 9984066133002771
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