Journal article
Poly(vinyl alcohol) tissue phantoms as a robust in vitro model for heat transfer
International journal of polymeric materials, Vol.65(15), pp.797-806
10/12/2016
DOI: 10.1080/00914037.2016.1171222
Abstract
Glutaraldehyde-crosslinked poly(vinyl alcohol) (PVA) was used to create pourable, volume-stable hydrogel tissue phantoms that demonstrate several advantages over traditional poly(acrylamide) phantoms. The crosslinker concentration, curing time, and curing temperature were tuned to produce a tissue phantom whose volume varied by <0.2% over a 25-day span. The thermal conductivity of the PVA phantoms was tuned across the physiological range from 0.475 to 0.795 W m
−1
°C
−1
by incorporating inert particle fillers. Experimental thermal diffusivity trials demonstrated the method's utility for creating reliable, versatile tissue phantoms for the in vitro study of heat transfer in biologically relevant scenarios.
Details
- Title: Subtitle
- Poly(vinyl alcohol) tissue phantoms as a robust in vitro model for heat transfer
- Creators
- Joel Coffel - University of IowaEric Nuxoll - University of Iowa
- Resource Type
- Journal article
- Publication Details
- International journal of polymeric materials, Vol.65(15), pp.797-806
- Publisher
- Taylor & Francis
- DOI
- 10.1080/00914037.2016.1171222
- ISSN
- 0091-4037
- eISSN
- 1563-535X
- Grant note
- The authors gratefully acknowledge support from the National Science Foundation (CBET-1133297) and the American Heart Association (11SDG7600044) for this work.
- Language
- English
- Date published
- 10/12/2016
- Academic Unit
- Chemical and Biochemical Engineering; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984197545302771
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