Journal article
Population-Based Assessment of HPV Genotype-Specific Cervical Cancer Survival: CDC Cancer Registry Sentinel Surveillance System
JNCI Cancer Spectrum, Vol.2(3), pky036
2018
DOI: 10.1093/jncics/pky036
PMID: 30596199
Abstract
Background: Human papillomavirus (HPV) genotype influences the development of invasive cervical cancer (ICC); however, there is uncertainty regarding the association of HPV genotype with survival among ICC patients.Methods: Follow-up data were collected from 693 previously selected and HPV-typed ICC cases that were part of the Centers for Disease Control and Prevention Cancer Registry Surveillance System. Cases were diagnosed between 1994 and 2005. The Kaplan-Meier method was used to estimate five-year all-cause survival. A multivariable Cox proportional hazards model was used to estimate the effect of HPV genotype on survival after adjusting for demographic, tumor, and treatment characteristics.Results: Five-year all-cause survival rates varied by HPV status (HPV 16: 66.9%, HPV 18: 65.7%, HPV 31/33/45/52/58: 70.8%, other oncogenic HPV genotypes: 79.0%, nononcogenic HPV: 69.3%, HPV-negative: 54.0%). Following multivariable adjustment, no statistically significant survival differences were found for ICC patients with HPV 16-positive tumors compared with women with tumors positive for HPV 18, other oncogenic HPV types, or HPV-negative tumors. Women with detectable HPV 31/33/33/45/52/58 had a statistically significant 40% reduced hazard of death at five years (95% confidence interval [CI] = 0.38 to 0.95), and women who tested positive for nononcogenic HPV genotypes had a statistically significant 57% reduced hazard of death at five years (95% CI = 0.19 to 0.96) compared with women with HPV 16 tumors. Few statistically significant differences in HPV positivity, tumor characteristics, treatment, or survival were found by race/ethnicity.Conclusions: HPV genotype statistically significantly influenced five-year survival rates among women with ICC; however, screening and HPV vaccination remain the most important factors to improve patient prognosis and prevent future cases.
Details
- Title: Subtitle
- Population-Based Assessment of HPV Genotype-Specific Cervical Cancer Survival: CDC Cancer Registry Sentinel Surveillance System
- Creators
- Benjamin HallowellMona SaraiyaTrevor ThompsonElizabeth UngerCharles LynchTom TuckerGlenn CopelandBrenda HernandezEdward PetersEdward WilkinsonMarc Goodmanfor the HPV Typing of Cancers Workgroup
- Resource Type
- Journal article
- Publication Details
- JNCI Cancer Spectrum, Vol.2(3), pky036
- DOI
- 10.1093/jncics/pky036
- PMID
- 30596199
- ISSN
- 2515-5091
- eISSN
- 2515-5091
- Grant note
- DOI: 10.13039/100000030, name: Centers for Disease Control and Prevention, award: 5U58DP000810-5, 5U58DP000844-5, 5U58DP000812-5, 5U58DP000769-5; name: Surveillance, Epidemiology, and End Result; name: National Institutes of Health, Department of Health and Human Services, award: N01-PC-35139, N01-PC-35143, N01-PC-35137; name: National Program of Cancer Registries, and genotyping; name: CDC intramural funds and Vaccine for Children Funds
- Language
- English
- Date published
- 2018
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995148902771
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