Journal article
Population-Based Surveillance of Birth Defects Potentially Related to Zika Virus Infection - 15 States and U.S. Territories, 2016
MMWR. Morbidity and mortality weekly report, Vol.67(3), pp.91-96
01/26/2018
DOI: 10.15585/mmwr.mm6703a2
PMCID: PMC5812309
PMID: 29370151
Abstract
Zika virus infection during pregnancy can cause serious birth defects, including microcephaly and brain abnormalities (1). Population-based birth defects surveillance systems are critical to monitor all infants and fetuses with birth defects potentially related to Zika virus infection, regardless of known exposure or laboratory evidence of Zika virus infection during pregnancy. CDC analyzed data from 15 U.S. jurisdictions conducting population-based surveillance for birth defects potentially related to Zika virus infection.* Jurisdictions were stratified into the following three groups: those with 1) documented local transmission of Zika virus during 2016; 2) one or more cases of confirmed, symptomatic, travel-associated Zika virus disease reported to CDC per 100,000 residents; and 3) less than one case of confirmed, symptomatic, travel-associated Zika virus disease reported to CDC per 100,000 residents. A total of 2,962 infants and fetuses (3.0 per 1,000 live births; 95% confidence interval [CI] = 2.9-3.2) (2) met the case definition.
In areas with local transmission there was a non-statistically significant increase in total birth defects potentially related to Zika virus infection from 2.8 cases per 1,000 live births in the first half of 2016 to 3.0 cases in the second half (p = 0.10). However, when neural tube defects and other early brain malformations (NTDs)
were excluded, the prevalence of birth defects strongly linked to congenital Zika virus infection increased significantly, from 2.0 cases per 1,000 live births in the first half of 2016 to 2.4 cases in the second half, an increase of 29 more cases than expected (p = 0.009). These findings underscore the importance of surveillance for birth defects potentially related to Zika virus infection and the need for continued monitoring in areas at risk for Zika.
Details
- Title: Subtitle
- Population-Based Surveillance of Birth Defects Potentially Related to Zika Virus Infection - 15 States and U.S. Territories, 2016
- Creators
- Augustina DelaneyCara MaiAshley SmootsJanet CraganSascha EllingtonPeter LangloisRebecca BreidenbachJane FornoffJulie DunnMahsa YazdyNancy Scotto-RosatoJoseph SweatlockDeborah FoxJessica PalaciosNina ForestieriVinita LeedomMary SmileyAmy NanceHeather Lake-BurgerPaul RomittiCarrie FallMiguel Valencia PradoJerusha BartonJ Michael BryanWilliam AriasSamara Viner BrownJonathan KimuraSylvia MannBrennan MartinLucia OrantesAmber TaylorJohn NahabedianAmanda AkosaZiwei SongStacey MartinRoshan RamlalCarrie Shapiro-MendozaJennifer IsenburgCynthia A MooreSuzanne GilboaMargaret A Honein
- Resource Type
- Journal article
- Publication Details
- MMWR. Morbidity and mortality weekly report, Vol.67(3), pp.91-96
- Publisher
- United States
- DOI
- 10.15585/mmwr.mm6703a2
- PMID
- 29370151
- PMCID
- PMC5812309
- ISSN
- 1545-861X
- eISSN
- 1545-861X
- Language
- English
- Date published
- 01/26/2018
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9983995046702771
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