Journal article
Population-Level Reduction in Ovarian Cancer Through Performance of Opportunistic Salpingectomy at the Time of Cholecystectomy
Annals of surgery
09/15/2025
DOI: 10.1097/SLA.0000000000006940
PMID: 40951975
Abstract
We estimated the population-level magnitude of reduction in incident ovarian cancer if opportunistic salpingectomy (OS) was implemented at the time of cholecystectomy (CCK).
Opportunistic salpingectomy (OS), prophylactic removal of the fallopian tubes, is a primary prevention strategy to reduce the risk of ovarian cancer.
We developed a methodological framework to estimate the benefit of OS-CCK for women. Population-level statistics were used to estimate the number of CCKs performed annually in the U.S. as well as the expected number of ovarian cancers, while accounting for competing risks of death. OS reduces the risk of ovarian cancer by 65%. We simulated the effect on ovarian cancer for up to 50 years if OS was performed in 40-80% of women undergoing CCK.
Implementation of OS in 40% of the CCKs women 40-44 years of age would prevent 6 cases of ovarian cancer within 5 years of follow-up, 41 cases within 20 years and 139 cases after 50 years of follow-up. If OS were performed in 80% of CCKs in this population, the corresponding cases prevented rises to 12 at 5 years, 81 at 20 years and 279 after 50 years follow-up. If OS were performed in 40% of all women ≥40 years of age who underwent CCK in given year, there would be 111 cases of ovarian cancer prevented after 5 years, 349 cases after 15 years, 660 cases after 30 years and 850 lifetime cases prevented.
OS at the time of cholecystectomy has the potential to significantly reduce the burden of ovarian cancer in the United States.
Details
- Title: Subtitle
- Population-Level Reduction in Ovarian Cancer Through Performance of Opportunistic Salpingectomy at the Time of Cholecystectomy
- Creators
- Jason D Wright - Columbia UniversityLing Chen - Columbia UniversityCarly Tymm - Columbia UniversityXiao Xu - Columbia UniversityJennifer S Ferris - Columbia UniversityDawn L Hershman - Columbia UniversityAndrea R Hagemann - Washington University in St. LouisDionne Skeete - University of IowaThomas Curran - Medical University of South CarolinaMaggie Westfal - Medical University of South CarolinaDavid Flum - University of WashingtonKatherine Fischkoff - Columbia University
- Resource Type
- Journal article
- Publication Details
- Annals of surgery
- DOI
- 10.1097/SLA.0000000000006940
- PMID
- 40951975
- NLM abbreviation
- Ann Surg
- ISSN
- 0003-4932
- eISSN
- 1528-1140
- Publisher
- Lippincott
- Language
- English
- Electronic publication date
- 09/15/2025
- Academic Unit
- Surgery; Injury Prevention Research Center
- Record Identifier
- 9984964235402771
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